A novel zinc porphyrin-containing polyimide (ZPCPI) nanofibrous membrane for rapid and reversible detection of trace amounts of pyridine vapor is described. The membrane displays a distinct color change, as well as dramatic variations in absorption and fluorescent emission spectra, upon exposure to pyridine vapor. This condition allows the detection of the analyte at concentrations as low as 0....

NQO1 is a FAD containing NAD(P)H-dependent oxidoreductase that catalyzes the reduction of quinones and related substrates. In cells, NQO1 participates in a number of binding interactions with other proteins and mRNA and these interactions may be influenced by the concentrations of reduced pyridine nucleotides. NAD(P)H can protect NQO1 from proteolytic digestion suggesting that binding of reduce...

EARLIER studies in our laboratory indicated the predominance of pentose cycle In addition a correlation was demonstrated between enzymes generating reduced triphosphopyridine nucleotide and lipid synthesis (Bieber, Cheldelin & Newburgh, 1962; Baker & Newburgh, 1963). Since several of the biosynthetic pathways involve this compound, it is conceivable that in a rapidly growing system such as the ...

The heterocyclic amines (HCAs) found in cooked meat are procarcinogens that are metabolically activated by N-hydroxylation followed by O-acetylation by the N-acetyltransferases NAT1 and NAT2. Despite the importance of metabolic activation in HCA carcinogenicity and the finding that several HCAs are rodent mammary gland carcinogens, nothing was known about O-acetylation activity in the human mam...

The reactivities of alkaline NH(2)OH and neutral NaHSO(3) with carbonyl and olefinic groups conjugated with the tetrapyrrole nucleus of haems were studied. The reactions were carried out with 2-3nmol of haem a, spirographis haem, isospirographis haem, 2,4-diacetyldeuterohaem and protohaem. Vinyl side chains were found to be insensitive to the chemical action of both alkaline NH(2)OH and neutral...

The concentration of pyridine nucleotides in the liver of the hyperthyroid rat is low (14). Whether this is a result of decreased synthesis, increased destruction, or both, is not known. Several groups of investigators have shown that when the normal rat or the normal mouse is given a single dose of nicotinamide the concentration of pyridine nucleotides in the liver rises rapidly for a few hour...

The asymmetric unit of the title compound,  Contains two independent molecules. The Cu atoms are four coordinated in distorted tetrahedral configuration by two atoms from 5,5`-dimethyl-2,2`- bipyridine and two terminal atoms. In the Cuystal structure, inter molecular hydrogen bonds link the molecules. The are  contacts between the methyl groups and the pyridine and five member rings containing ...

Recently, stable diazoalkenes have received significant attention as a new substance class in organic chemistry. While their previous synthetic access was exclusively limited to the activation of nitrous oxide, we here establish much more general approach utilizing Regitz-type diazo transfer with azides. Importantly, this is also applicable weakly polarized olefins such 2-pyridine olefins. The ...

In this protocol, 3-(2-carboxybenzoyl)-1-methyl-1H-imidazol-3-ium chloride [Cbmim]Cl and sulfonic acid functionalized pyridinium chloride [pyridine-SO3H]Cl as a new, reusable, and green Brønsted acidic ionic liquid (BAIL) catalyst were synthesized and successfully used for the one-pot ring opening of epoxide with sodium azide (NaN3) in water at room temperature. Epoxides under ring-opening easi...

This article outlines the current concept of attention deficit hyperactivity disorder (ADHD) pathogenesis from standpoint neuroanatomy and impairments neurotransmitter metabolism. N-acetyl-aspartate N-acetyl-aspartyl-glutamate are crucial for ADHD development. These substances involved in interaction neuronal networks, myelin maturation, functioning excitatory neurotransmitters (glutamatergic s...