Background and objectives: Alzheimer's disease (AD) is an age dependent disorder. AD is associated with decrease of brain acetylcholine level. Nowadays, one of the methods for progression inhibition of AD is using acetylcholinesterase inhibitors. Rosaceae is a large plant family. Different biological effects of some species of this family have been reported. The aim of the present study was to ...

Molecular docking is emerging as a frequently applied structure-based virtual technique in the drug design processes. The method could significantly reduce time required for development of novel and effective molecules compared to high-throughput screening. However, major drawback simulations high number false-positive ligands top-ranked solutions. Thus, this work focuses on optimization geneti...

Generic Name: Galantamine Brand Name: Reminyl® Manufacturer: Shire Pharmaceuticals and Janssen Cilag (http://www.janssenpharmaceutica.be/index_N.asp) Summary: Galantamine hydrobromide, a phenanthrene alkaloid, is a reversible, competitive acetylcholinesterase inhibitor that is structurally unrelated to other acetylcholinesterase inhibitors (e.g, donepezil, rivastigmine, tacrine). Galantamine hy...

We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), with IC(50) values in the micromolar range. In vitro studies show that they are mixed inhibitors of the enzyme, and thus the ternary enzyme-inhibitor-substrate complex can f...