The investigation of a dichloromethane extract of flower heads of a Hungarian taxon of the Achillea millefolium group led to the isolation of three flavonoid aglycones, one triterpene, one germacranolide and five guaianolides. Their structures were elucidated by UV-VIS, EI- and CI-MS, 1H NMR and 13C NMR spectroscopic methods as well as by 2D-NMR studies and by selective 1D-NOE experiments. Besi...

The aim of this study was to explore the acetylcholinesterase (AChE) inhibition of several Icelandic medicinal herbs. Ethanolic extracts of Angelica archangelica seeds and the aerial parts of Geranium sylvaticum proved effective, with IC50 values of 2.20 mg/ml and 3.56 mg/ml, respectively. The activity of imperatorin and xanthotoxin from A. archangelica was measured. Xanthotoxin proved much mor...

Type 2 diabetes (T2D) is a chronic disease with growing prevalence worldwide. In addition to the conventional therapy, many T2D patients use phytotherapeutic preparations. present study, chemical composition, antioxidant, and α-glucosidase inhibiting activity of traditional antidiabetics from Croatian ethnomedicine (Achillea millefolium, Artemisia absinthium, Centaurium erythraea, Morusalba, Ph...

Essential oils from plants used in traditional medicine are known as a rich source of chemically diverse compounds with specific biological activities. Achillea millefolium essential oil (AEO) was screened for vitro activity against Babesia canis. The AEO obtained by hydrodistillation and analysed gas chromatography coupled to mass spectrometry (GC-MS). GC-MS revealed the presence 47 oil. Those...

Achillea millefolium (AM) is widely used in traditional medicine a wide geography due to its effects on the female reproductive system. However, effect uterine smooth muscle contractions unknown. Our study aims investigate of AM spontaneous and oxytocin-induced isolated rat contractions. Myometrial strips were obtained from 32 adult Wistar Albino rats. Contraction amplitudes frequencies recorde...

Oxidative stress is known to play a vital role in the progression of neurodegenerative diseases. The current treatment method primarily targets symptoms by using anti-Parkinson drugs such as levodopa, carbidopa, dopamine (DA) agonists, monoamine oxidase type B inhibitors, and anticholinergics replace DA. However, these pose severe side effects when used for prolonged time. Hence, there need con...