The basal transcription factor TFIID consists of the TATA-binding protein (TBP) and TBP-associated factors (TAFs). Yeast Taf67 is homologous to mammalian TAF(II)55. Using a yeast two-hybrid screen to identify proteins that interact with Taf67, we isolated Bromodomain factor 1 (Bdf1) and its homolog (Bdf2). The Bdf proteins are genetically redundant, as cells are inviable without at least one of...

The synthesis and the spectroscopic characterization of fluoride-alkoxides of niobium and tantalum in the highest oxidation state are reported. Suspensions of MF(5) (M = Nb, Ta) in a chlorinated solvent reacted with up to three equivalents of ROSiMe(3) (R = Me, Et, Ph) to afford polynuclear derivatives and variable amounts of FSiMe(3). Thus MF(4)(OR) (R = Et, Ph) and MF(3)(OR)(2) were obtained ...

Contents Software Productivity Consortium (Consortium) members applying the tools for both the requirement and design model-driven verification and validation are often required to certify their software with various certification authorities such as the Federal Aviation Administration (FAA) and Food and Drug Administration (FDA). These certifications require methods and supporting artifacts fo...

Emtricitabine (FTC) plus tenofovir alafenamide (TAF) has demonstrated efficacy and safety for pre-exposure prophylaxis (PrEP) to prevent HIV-1 infection. We measured the plasma PK of FTC, (TFV), TAF in a steady-state pharmacokinetic (PK) study bictegravir/FTC/TAF HIV-1-infected patients. Furthermore, validated liquid chromatography-tandem mass spectrometry was used measure intracellular TFV-dip...

Investigations into long-term geomagnetic variations provide useful information regarding paleomagnetic field behavior. In this study, we assess the latitudinal structure of paleosecular variation (PSV) and time-averaged (TAF) for Brunhes normal Matuyama reverse chrons, 0–10 Ma period, from an updated reviewed paleodirectional database spanning past 10 Myr. The new comprises 2,543 sites igneous...

Virtual agents are used by the military for extensive training of pilots. However, creating virtual agents with the appropriate behaviors is a lengthy and specialized process. We describe a new tool (TAF) to allow rapid creation of virtual adversarial agents by non-specialized personnel. In TAF, users can draw diagrams of agent behavior which are matched within a pre-existing knowledge base. By...

In this paper we present the method of lines for the numerical solution of a mathematical model for capillary formation in two space dimensions x,y. We study the tumor angiogenic factor (TAF) equation, and suppose there is no tumor source supplied to the system for simplicity. This method is an approach to the numerical solution of partial differential equations that involve a time variable t a...

INTRODUCTION The efficacy, safety and tolerability of the preservative-free (PF) fixed combination (FC) of tafluprost 0.0015% and timolol 0.5% (once daily) were compared to those of the individual components (PF tafluprost 0.0015% once daily and PF timolol 0.5% twice daily) in patients with open-angle glaucoma or ocular hypertension inadequately controlled on prior timolol or prostaglandin mono...

The objective of this research was to study the ameliorative effects of a standardized quassinoid-rich extract (TAF 273) of Eurycoma longifolia root on some reproductive disorders in female rats. An irregular estrous cycle and ovarian cystic follicles were induced in 21-day-old females by the daily administration of testosterone (10 mg/kg, sc) for three weeks. The hormone-treated rats exhibited...