Concentrated and partially purified preparations of streptococcal supernates containing streptolysin O have been shown to inhibit selectively the oxidative metabolism of mitochondria procured from the myocardium of rabbits and guinea pigs, the findings pointing to an interference with the action of the coenzyme diphosphopyridine nucleotide (DPN) (1). Further studies have demonstrated that these...

Taking medications during breastfeeding is common and physicians are usually asked about the safety of prescribed medicines, herbal medications, or tobacco and alcohol consumption during lactation. Safety of medications during breastfeeding is related to maternal factors, neonatal factors and the type of medication, In the case of necessity of taking medication for the mother, there are ways to...

Klein (1) has made a detailed investigation of the action of “purine nucleosidase” on the various purine desoxyribosides. He found that preparations of animal tissues which split purine ribosides also split the purine desoxyribosides, yielding the purine base and a reducing sugar. The enzyme preparations were inactivated upon dialysis, but could be reactivated by the addition of arsenate or pho...

Arsenic is a kind of necessary trace elements of livestock and poultry nutrition, and plays an important role in the tissues and organs and metabolism, etc. With the rapid development of feed industry, the organic arsine preparations of feed additives have been widely applied in animal husbandry. But these organic arsine preparations are absorbed less in animal body, and large amount of them ar...

The aim of the study was to assess the effect of lysozyme monomer and dimer as well as modified lysozyme preparations on the shelf life of chicken carcass elements (breast muscles) cold stored at 3°C±1°C. Total counts of aerobic bacteria were determined and sensory examination of the product was conducted. Analyses showed that surface application of dimer solutions and modified lysozyme prepara...

Stimulated labeling of phospholipids from 32p i is a hallmark of activation of a variety of cell surface receptors. In the case of the central nervous system, the response can ref lect muscarinic activation. Recent studies in nerve ending preparations indicate a postsynaptic site of action. Ca 2+ is required for the expression of cholinergic stimulation of labeling in nerve ending preparations,...

We examined the possible role of the Na-Ca exchange (NCX) in the arrhythmogenesis in rat atrial preparations applying microelectrode technique. In control Tyrode solution preparations isolated from the sinoatrial area contracted with frequency of 48+/-4 min(-1) (group I) or 84+/-7 min(-1) (group II). In preparation beating with low frequency partial inhibition of NCX by administration of Ni2+ (...

The enzyme preparations used in this study consisted of particulate fractions from frozen chicken liver or fresh rat liver isolated from 0.25 M sucrose homogenates by a method already described (1). These preparations contained both mitochondria and microsomes. The enzyme was suspended in 0.02 M Tris buffer of pH 8.0 containing 0.001 M Versene in a concentration of 20 to 40 mg. per ml. and coul...

The effect of moderate elevation in extracellular potassium concentration (up to 12 mM) on contraction of cat ventricular muscle was examined. Isometric force development was recorded from eight excised trabeculae and from six coronary-perfused in situ papillary muscle preparations. Contraction in the steady state was variably affected, sometimes decreasing monotonically, sometimes remaining un...

The underlying mechanism involved in the interaction between neutrophil elastase inhibitors and tachykinins has not been elucidated. In this study we have examined the effects of sivelestat, a neutrophil elastase inhibitor, on the in vitro responses of airways from lipopolysaccharide (LPS)-untreated or -treated guinea-pigs to substance P. Substance P (0.01-30 micromol/l) produced concentration-...