This study describes the synthesis and antioxidant activity of new 1,4-disubstituted 1,2,3-triazoles. These compounds were generated semi-synthetically using Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) reaction between ethyl 2-azidoacetate terminal acetylenes derived from natural products carvacrol, eugenol, isovanillin, thymol vanillin. The obtained at 50 to 80% yield characterised thro...

We demonstrate selective functionalization of independently addressed microelectrodes by electrochemical activation and deactivation of a coupling catalyst. 1,2,3-Triazole formation between terminal acetylenes and organic azides is efficiently catalyzed by copper(I) complexes (a Sharpless "click" reaction), while the oxidized copper(II) complexes are inactive. By electrochemically activating or...

Alkynylphosphines or their borane complexes are available either through C-P bond forming reactions or through modification of the phosphorus or the alkynyl function of various alkynyl phosphorus derivatives. The latter strategy, and in particular the one involving phosphoryl reduction by alanes or silanes, is the method of choice for preparing primary and secondary alkynylphosphines, while the...

One of the major challenges faced by organic chemistry is the efficient synthesis of increasingly complex molecules. Since October 2007, the Laboratory of Catalysis and Organic Synthesis (LCSO) at EPFL has been working on the development of catalytic reactions based on the Umpolung of the innate reactivity of functional groups. Electrophilic acetylene synthons have been developed using the exce...

introduction: carbamazepine is commonly used in a variety of indications. poisoning by this drug, can lead to coma, seizures, cardiac disorders and respiratory distress. the treatment of poisoning is generally supportive. method: 68 poisoned patients with carbamazepine, who referred to poisoning ward of loghman hospital, from july 2003 to september 2004, were studied. these patients were invest...