PURPOSE To determine the accessibility of treatment and the quality of antiepileptic drugs (AEDs) in the Haute Matsiatra district of Madagascar. METHODS Cross-sectional descriptive study and interviews. Samples of 10 units of each available AED were collected, and the active ingredient was quantified by reversed-phase high-performance liquid chromatography (RP-HPLC) with photodiode-array UV d...

BACKGROUND Antimalaria treatment failure has been partly attributed to poor quality antimalarials in the drug market. A 1998 survey in Kampala showed that 55% of tablets and 62% of injection forms of chloroquine failed the quality test. OBJECTIVE This study was carried out as a follow-up to establish the quality of chloroquine tablet and injection dosage forms in the Ugandan drug market from ...

Phenylethanoid glycosides (PhGs), a class of polyphenolic compounds, are considered one of major bioactive constituents of Cistanche deserticola Y.C. Ma (CD), whose extract is orally used in traditional Chinese medicine. Although previous pharmacological studies have reported that PhGs exert many activities, their intestinal transport profiles have not been clarified. In this study, we investig...

This study reported that the sample used in was an infusion using fresh coriander leaves samples taken Lubuk Pakam area. Several studies have shown active components of seeds are essential oils such as sabiene, myrcene, alphaterpine, ocimene, linalool, graniol, decanal, desilaldehyde, trantridecen, petroselinic acid, octadesenic d-mannite, scopoletin, psimena, kamfena and felandren. These cause...

After a historical introduction to Poisson’s equation for Newtonian gravity, its analog for static gravitational fields in Einstein’s theory is reviewed. It appears that the pressure contribution to the active mass density in Einstein’s theory might also be noticeable at the Newtonian level. A form of its surprising appearance, first noticed by Richard Chase Tolman, was discussed half a century...

inclined retaining walls with slopes less than perpendicular are appropriate candidates in several engineering problems. yet, to the knowledge of authors, only a few analytical solution for calculation of active earth pressure on such walls, which will be usually smaller than the same pressure on vertical ones, has been presented neither in research papers nor in design codes. considering limit...

A systematic optimization of the HPLC separation of a complex mixture containing 19 diuretics by micellar liquid chromatography using sodium dodecyl sulphate (SDS), a Hypersil (150 mmx3.0 mm I.D., 5 microm) C18 column, a flow-rate of 0.5 ml min(-1) and UV absorbance detection has been carried out. Several mobile phases consisting of SDS and organic modifiers such as acetonitrile, tetrahydrofura...

OBJECTIVES This study is part of a programme on reduction of postpartum haemorrhage (PPH). Ergometrine and methylergometrine have a favourable effect on both blood loss and maternal morbidity and mortality and oral preparations were regarded as a possible treatment for use in tropical countries. The stability of oral preparations of the two ergometrine compounds under tropical conditions was un...

An analytical method to evaluate propionylpromazine hydrochloride (PPZHCl) in tranquilizer formulations was developed using high-performance liquid chromatography (HPLC). During analysis of aged quality-control samples, a previously unreported chromatographic response was observed at a shorter retention time than PPZHCl. Further investigation of formulations stored in trap tap devices at temper...