Autor opracowania skupił swoją uwagę na interpretacji kanonów 190-191 KPK, które dotyczą przeniesienia z urzędu kościelnego. Z przeprowadzonych analiz wynika, że ​​w prawie kanonicznym, oprócz papieża, przeniesiony może zostać każdy, kto pełni urząd kościelny. Najogólniej rzecz ujmując, doktryna wyróżnia dwa rodzaje – dobrowolne i niedobrowolne. Należy podkreślić, pierwsze od nigdy nie jest pos...

BACKGROUND MicroRNAs (miRNAs) are small, noncoding RNAs (ribonucleic acids) that regulate translation. Several miRNAs have been shown to be altered in whole cancer tissue compared to normal tissue when quantified by microarray. Based on previous such evidence of differential expression, we chose to study the functional significance of miRNAs miR-30a and -191 alterations in human lung cancer. ...

BACKGROUND ITMN-191 (RG7227, Danoprevir), as a potential inhibitor of the NS3/4A protease of hepatitis C virus, has been in phase 2 clinical trial. Unfortunately, several ITMN-191 resistance mutants including R155K, A156V, and D168A/E have been identified. METHODS Molecular dynamics simulation, binding free energy calculation and per-residue energy decomposition were employed to explore the b...

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The analysis of the hyperlink structure of the web has led to significant improvements in web information retrieval. This survey describes two successful link analysis algorithms and the state-of-the art of the field.

Quantitative modeling has revolutionized modern biology. The ability to reduce biological processes to sets of equations enables us to reproduce many features of the living system: complex nonlinear systems can defy intuition, and sometimes the best way to put a given finding into perspective is to simulate it. More importantly, quantitative modeling can yield emergent insights. We do our best ...

The hyperlinking feature of hypertext, which in the cognitive flexibility perspective encourages advanced learning (Spiro & Jehng, 1990), frequently overloads working memory according to the cognitive load theory (Sweller, 1988). One of such negative effects of hyperlinks is split attention. When two or more sources of information are separated in space (e.g., text located on different hypertex...

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