Amphotericin B (AMB) is a highly hydrophobic antifungal, whose use is limited by its toxicity and poor solubility. To improve its solubility, AMB was reacted with a functionalized polyethylene glycol (PEG), yielding soluble complex AmB-PEG formulations that theoretically comprise of chemically conjugated AMB-PEG and free AMB that is physically associated with the conjugate. Reverse-phase chroma...

Active magnetic bearings (AMBs) have led to great progress in the field of rotating machinery due their many advantages, such as non-contact and non-lubrication properties. As key component an AMB actuator, switching power amplifier has important impact on performance machinery. In this paper, topologies amplifiers for AMBs are introduced. The traditional half-bridge topology two newly proposed...

Enzymes are versatile catalysts in laboratories and on an industrial scale; improving their immobilization would be beneficial to broadening their applicability and ensuring their (re)use. Lipid-coated nano-magnets produced by magnetotactic bacteria are suitable for a universally applicable single-step method of enzyme immobilization. By genetically functionalizing the membrane surrounding thes...

OBJECTIVES The pharmacokinetics of lipid-formulated amphotericin B (AMB), and of AMB that has dissociated from its lipid moiety and bound to lipoproteins in plasma, were separately determined in critically ill patients. PATIENTS AND METHODS Eleven patients required continuous veno-venous haemofiltration (CVVH). Five of them were treated with liposomal AMB (AmBisome) and seven with AMB colloid...

Active magnetic bearings offer the capability to control rotor vibration and transmitted forces through the design of adaptive controllers. These controllers can take into account the changing operating conditions and variations in the system dynamics. A Recursive Open-Loop Adaptive Control (ROLAC) algorithm was developed, which minimizes the sum of squares of the measurements in frequency doma...