The aim of the investigation was to reveal changes in neurons cerebral cortex depending on dose γ-irradiation, rate exposure, mode exposure (acute and chronic) establish priority each influencing factors (γ-irradiation, recovery time their joint impact) end result. Material methods . experiment, compliance with rules bioethics, carried out 300 adult white rats that were exposed acute chronic γ-...

Previous studies have primarily interpreted gene expression regulation by glucocorticoids in the brain in terms of impact on neurons; however, less is known about the corresponding impact of glucocorticoids on glia and specifically astrocytes in vivo. Recent microarray experiments have identified glucocorticoid-sensitive mRNAs in primary astrocyte cell culture, including a number of mRNAs that ...

BACKGROUND There is a need for agents that suppress inflammation and progression of chronic obstructive pulmonary disease. p38 mitogen-activated protein kinase (p38 MAPK) has been associated with this disorder, and several inhibitors of this cascade are in clinical trials for its treatment, but their efficacy and utility are unknown. This study evaluated the relationship between p38 MAPK activa...

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in synaptic function are prominent among these effects. Acute exposure to EtOH activates or inhibits the function of proteins involved in synaptic transmission, while chronic exposure often produces opposing and/or compensatory/homeostatic effects on the expression, localization, and function of these proteins. I...

BACKGROUND Cardiovascular disease is an important cause of morbidity and mortality among tobacco users. Varenicline is widely used worldwide to help smoking cessation, but some published studies have reported associated cardiovascular events. OBJECTIVE To determine the cardiovascular toxicity induced by varenicline in rats. MATERIALS AND METHODS We randomly separated 34 rats into two groups...

Background: N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses.Methods: Following intraperitoneal (i.p.) administration of N...

Background: Polycyclic aromatic hydrocarbons (PAHs) such as naphthalene (NAP) are organic pollutants that have spread widely in littoral marine ecosystems. We aimed to study the effect of acute and prolonged exposure to naphthalene (NAP) on plasma cortisol and thyroid levels in mature and immature Liza klunzingeri mulet. Methods: In acute stress experiment, the treatment group received 2μ...

Recent epidemiological reports showed that smoking has a negative impact on renal function and elevates the renal risk not only in the renal patient but perhaps also in the healthy population. Studies suggested that nicotine, a major tobacco alkaloid, links smoking to renal dysfunction. While several studies showed that smoking/chronic nicotine exposure exacerbates the progression of chronic re...