A 10-year-old boy presented with right proptosis for 8 months. The eyeball was grossly pushed down, with diffuse corneal haze and non-reactive pupil. Systemic examination was normal. Previous investigations in another centre included a computerized tomography scan, which showed a well-defined enhancing retro-bulbar mass, a non-contributory fine needle aspiration cytology and a biopsy showing fi...

Chemotherapeutic agents such as procarbazine, which produce meth ylated bases in DNA, are used to treat many Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) patients. A small proportion of such patients develop secondary malignancy. We examined the possibility that those patients who develop secondary malignancy have low endoge nous levels of 06-alkylguanine DNA alkyltransferase (ACT) a...

Non-Hodgkin lymphoma (NHL) comprises of heterogeneous group lymphoid malignancies originating from lympho-reticular tissues and is quite uncommon in pregnancy (0.8 cases per 1,00,000 women). Anaplastic large cell (ALCL) a large-cell neoplasm with anaplastic morphology classified under NHL. Here, 31 year old primigravida diagnosed NHL ALCL subtype third trimester, started on chemotherapy which r...

The cytoplasmic (175,000 x g supernatant) and the chromatin fractions from phytohemagglutinin-stimulated normal human lymphocytes, human thymus tissue, lympho cytes from chronic lymphocytic leukemia and acute lymphoblastic leukemia patients and cultured cells of normal (RPMI 1788), multiple myeloma (RPMI 8226), Burkitt lymphoma (HR1K), and acute lymphoblastic leukemia (Molt-4) origin were exami...

Mycobacterium tuberculosis remains a pathogen of con¬ siderable clinical and public health importance. Clas¬ sically, tuberculous pleuritis was regarded as a disease ofyoung adults characterized by a unilateral, lymphocytic exudate with a self-limited short-term course. In the last two decades, how¬ ever, there has been increasing recognition that tuberculous pleuritis is occurring in an older ...

T HERE ARE numerous conflicting concepts in respect to the function, fate and life span of lymphocytes.15 Radiation of segments of the wholebody or of lymphocytes in vitro has long been exploited in the study of lymphocytes.69 However, irradiation of the whole-body or segments injures lymphopoietic tissue and the in vitro environment separates the lymphocyte from homeostatic influences. We reas...

Gap junctions are clusters of intercellular channels directly connecting the cytoplasm of adjacent cells. These channels are formed by proteins named connexins and are present in all metazoan organisms where they serve diverse functions ranging from control of cell growth and differentiation to electric conduction in excitable tissues. In this overview we describe the presence of connexins in t...