We compared the incidence of submicroscopic deletions accompanying balanced translocations using interphase fluorescence in situ hybridization (FISH) in 245 patients with chronic myeloid leukemia (CML), 79 patients with acute lymphoblastic leukemia (ALL) and BCR-ABL (n=70) or MLL rearrangements (n=29), and 412 patients with acute myeloid leukemia (AML) with CBFB-MYH11 (n=122), PML-RARalpha (n=1...

Somatic mutations of DNMT3A gene have recently been reported in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We examined the entire coding sequences of DNMT3A gene by high-resolution melting analysis and sequencing in Chinese patients with myeloid malignancies. R882 mutations were found in 12/182 AML and in 4/51 MDS, but not in either 79 chronic myeloid leukemia (CML), or 57...

Despite continuous advances in the knowledge of the biology of acute myeloid leukemia (AML), the prognosis of AML patients treated with standard chemotherapy is still poor, especially in the elderly (> 60 y). It should be considered that AML mainly develops in the elderly, with a median age at diagnosis of 68 y and a growing incidence over 65 y. AML accounts for about 25% of all adult leukemias...

Background: DNA microarray is a useful technology that simultaneously assesses the expression of thousands of genes. It can be utilized for the detection of cancer types and cancer biomarkers. This study aimed to predict blood cancer using leukemia gene expression data and a robust ℓ2,p-norm sparsity-based gene selection method. Materials and Methods: In this descriptive study, the microarray ...

Considerable progress has been achieved in the treatment of patients with acute promyelocytic leukemia (APL) by using retinoic acid and/or arsenic trioxide. However, it is generally considered that an effective agent which induces differentiation of myeloid leukemic cells has not been provided for the treatment of patients with other subtypes of acute myeloblastic leukemia (AML). On the other h...

Objective: To analyze the expression and clinical significance of miRNA-495 in peripheral blood patients with acute myeloid leukemia. Methods: Fifty-six leukemia 56 healthy controls were selected. Fasting venous was drawn centrifuged, plasma collected. The target miRNA directly amplified reverse transcribed into cDNA. miR-495 detected by qRT-PCR. Results: level newly diagnosed (AML [ND]) relaps...

introduction: the secondary genetic changes other than the pml-rara fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia (aml). however, the prognostic significance of flt3 mutations in acute promyelocytic leukemia (apl) is not firmly established....

endocarditis due to aspergillus infection is a rare complication in patients with hematological malignancies. here, we present a case of aspergillus endocarditis in a patient with acute myeloid leukemia (aml) successfully treated with antifungal therapy and surgical treatment. the patient was a 51 years old male, a known case of aml who was admitted to our medical center for evacuating his valv...

maintenance treatment for patients with acute myeloid leukemia (aml) in remission has recently been controversially discussed and even abandoned by several groups. an analysis of 16 published multicenter trials, however, revealed the highest probabilities of relapse free survival (rfs) in the range of 35-42 % at 4-5 years only in patients assigned to maintenance treatment when adult age and int...

We document findings on c-kit (CD117) expression in 1,937 pediatric and adult de novo acute leukemia cases, diagnosed in five single European centers. All cases were well characterized as to the morphologic, cytochemical, and immunologic features, according to the European Group for the Immunological Classification of Leukemias (EGIL). The cases included 1,103 acute myeloid leukemia (AML), 819 ...