Despite its widespread existence, there are relatively few drugs that can inhibit the progression of osteoarthritis (OA). Syndecan-4 (SDC4) is a transmembrane heparan sulfate proteoglycan modulates cellular interactions with extracellular matrix. Upregulated SDC4 expression in articular cartilage chondrocytes correlates OA progression. In present study, we treated osteoarthritic to elucidate ro...

Advances in biology have allowed us to substantially deepen our knowledge about hemostasis functioning both health and disease. ADAMTS-13 (a disintegrin metalloproteinase with thrombospondin type 1 motif, member 13) von Willebrand factor (vWF) are components of the system, which physiological interaction holds an important place maintaining homeostasis. is a mainly acting release vWF fragments ...

A 26-year-old black woman, without risk factors for coronary artery disease, was admitted in the cardiology department of our institution for acute chest pain. Three months before admission, she had an episode of abdominal pain along with fever, thrombocytopenia (platelet count 23 000/mm), and hemolytic anemia (hemoglobin 5.1 g/dL). Thrombotic thrombocytopenic purpura was diagnosed with ADAMTS-...

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening multisystem disease secondary to platelet aggregation. We present a patient who developed profound thrombocytopenia and anemia 8 days following initiation of therapy with clopidogrel after stent placement for carotid artery dissection. She did not have a disintegrin and metalloproteinase with thrombospondin domain 13 (ADAMTS 13) de...