Angiogenesis is controlled by signals that stimulate motility in endothelial cells at the tips of vascular sprouts while maintaining cell-cell adhesion in the stalks of angiogenic sprouts. We show here that Gs-linked G protein–coupled receptor activation of cAMP-dependent protein kinase (PKA) plays an important role in regulating the switch between endothelial cell adhesion and migration by act...

Atomic force microscopy was used to study adsorption and adhesion peculiarities of interferon α-2a on glass and mica surfaces. The specific protein adsorption behavior as a function of the pH value was illustrated on mica by single molecule imaging, while adhesion forces between interferon molecules and inner surfaces of borosilicate glass vials were measured directly under aqueous buffer condi...

Candida albicans is a normal microbiota in humans. However, the imbalance and increasing number of C. can cause infections vagina, mouth, esophagus, nails. Sap-3 plays role especially adhesion process, used as therapeutic target for C.albicans. Here an attempt has been made to analyze potential active compounds from noni (Morinda citrifolia) antifungal by molecular docking towards protein. Drug...

BACKGROUND/AIMS The study aims to determine the effects of thermal preconditioning on tendon adhesion by regulating the expression of heat shock protein 72 (HSP72) in rat models. METHODS Sixty male Wistar rats were collected and randomly assigned into the thermal preconditioning and control groups. During the 4th and 8th weeks following surgery, 15 rats were sacrificed in each period respecti...

Surfaces coated with polyzwitterions are most well-known for their ability to resist protein adsorption. In this article, a surface-attached hydrophobically modified poly(carboxybetaine) is presented. When protonated by changes of the pH surrounding medium, protein-repellent polyzwitterion switches polycationic state in which it antimicrobially active and protein-adhesive. The range these two s...