BACKGROUND Autologous fat grafting evolved over the twentieth century to become a quick, safe, and reliable method for restoring volume. However, autologous fat grafts have some problems including uncertain viability of the grafted fat and a low rate of graft survival. To overcome the problems associated with autologous fat grafts, we used uncultured adipose tissue-derived stromal cell (stromal...

Heart failure often develops after acute myocardial infarction because the injured myocardial tissue fails to recover or regenerate. Stem cell transplantation using adult cell sources, such as adipose-derived stromal vascular fraction (SVF), draws extensive attention. In this study, SVF cells were isolated from rat adipose tissue and cultivated on enzyme-crosslinked gelatin hydrogels. Morpholog...

Leptin has been shown to reduce body fat in vivo. Adipocytes express the leptin receptor, so it is realistic to expect a direct effect of leptin on adipocyte growth and metabolism. However, in vitro studies examining the effect of leptin on adipocyte metabolism require supraphysiologic doses of the protein to see a decrease in lipogenesis or stimulation of lipolysis, implying an indirect action...