نتایج جستجو برای: adna
تعداد نتایج: 215 فیلتر نتایج به سال:
PARP enzyme plays a key role in the cellular machinery responsible for DNA damage repair. PTEN is a tumorsuppressor gene deactivating PI3KdownstreamofEGFR signaling.Wehypothesize thatPTEN-deficient lung cancer cells suppressed DNA damage signaling and that the absence of PTEN can sensitize these cells to a concurrent treatment of aDNA-damaging agent (cisplatin) and a PARP inhibitor (olaparib). ...
After discovery of right handed double helical BDNA structure few more structures of DNA were discovered including left handed ZDNA. Researchers found out that variation in DNA structure was due to the variation in base sequence and dinucleotide step parameters. DNA in its most predomient form DNA is straight. But around 1980 it was observed that sequences /structure variation can create a bend...
The term “bioarchaeology” has its intellectual origins in the United Kingdom and the United States in the 1970s. Its meaning has evolved over the years (see Buikstra, 2006: xvii–xix), but it is now generally agreed to refer to reconstructions of past people’s lives based on a multidisciplinary analysis of archaeological human remains. Research designs are based on individual‐ or population‐leve...
Seventy-one individuals from the late Neolithic population of the 7000-year-old site of Hódmezővásárhely-Gorzsa were examined for their skeletal palaeopathology. This revealed numerous cases of infections and non-specific stress indicators in juveniles and adults, metabolic diseases in juveniles, and evidence of trauma and mechanical changes in adults. Several cases showed potential signs of tu...
BACKGROUND A major challenge for ancient DNA (aDNA) studies on insect remains is that sampling procedures involve at least partial destruction of the specimens. A recent extraction protocol reveals the possibility of obtaining DNA from past insect remains without causing visual morphological damage. We test the applicability of this protocol on historic museum beetle specimens dating back to AD...
Ancient DNA (aDNA) provides powerful evidence for detecting the genetic basis for adaptation to environmental change in many taxa. Among the greatest of changes in our biosphere within the last century is rapid anthropogenic ocean warming. This phenomenon threatens corals with extinction, evidenced by the increasing observation of widespread mortality following mass bleaching events. There is s...
Metal ions can bind to DNA directly or indirectly through hydrogen bonding of the coordinating water molecules surrounding the metal ions. Metal binding to the bases usually disrupts base pair hydrogen bonding and destabilizes the double helix. Spectroscopic and X-ray data shows that the N7 atom of the purine or N3 of pyrimidine residues as well as exocyclic O atoms and the phosphate oxygen ato...
The rich fossil record of the family Equidae (Mammalia: Perissodactyla) over the past 55 MY has made it an icon for the patterns and processes of macroevolution. Despite this, many aspects of equid phylogenetic relationships and taxonomy remain unresolved. Recent genetic analyses of extinct equids have revealed unexpected evolutionary patterns and a need for major revisions at the generic, subg...
FaRhaD KhoSRaVI, BEnJamIn KIng, SESh RaI, goEtz KloEcKER, ERIc WIcKStRom, anD BalaJI PanchaPaKESan Nanotube Devices for Digital Profiling CirCulating tumor Cells (CtCs) were f irst discovered in 1869 in the blood of patients suffering from metastatic disease by an australian physician, thomas ashworth, using optical microscopy [1]. the current understanding is that these CtCs mediate the spread...
We aimed to extract DNA and amplify PCR fragments at the mitochondrial Nad7.1 locus 11 nuclear microsatellite loci in nine circa 11,000-year-old individuals of Scots pine found bottom Baltic sea test genetic associations with present-day gene pool Lithuania. followed a strict anticontamination protocol lab and, simultaneously aDNA specimens, tested DNA-free controls. The was extracted by an ATM...
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