Plasma catecholamine (CA) concentrations, mean arterial pressure (MAP) and plasma corticosteroids were measured in fifteen unsupplemented glucocorticoid-treated patients undergoing major surgery. Eight patients had normal and seven patients had reduced plasma corticosteroid concentrations. Changes in plasma CA and MAP during surgery were not related to adrenocortical function. Two patients deve...

in asthma The study by Wolfe et al certainly does not support our claim that serious asthma exacerbations are more frequent in patients receiving formoterol 24 μg twice daily than in those receiving 12 μg twice daily, or placebo. Actually, this statement should have been based on the review by Mann et al, that assessed data from three prospective, randomised, placebo-controlled and double-blind...

The adrenogenital syndrom e is a result of the deficiency of one of the enzymes involved in the pathway leading to the synthesis of cortisol by the adrenal cortex. Laboratory evaluation of the adrenogenital syndrome involves m easurem ent of horm ones and metabolites accum ulated prior to the enzymic block as well as hormones whose synthesis is affected by deficiency of a specific enzyme. Labor...

The purpose of this study was to compare the effectiveness of flunisolide aerosol prescribed as .5 mg (two inhalations) twice daily and placebo In terms of oral steroid sparing ability in a population of 32 known steroid-dependent children and adolescents. Patients were stabilized on the lowest tolerated dose of daily AM or alternate AM oral corticosteroid for at least one month before entering...

OBJECTIVE To assess asthma patients in Brazil in terms of the level of asthma control, compliance with maintenance treatment, and the use of rescue medication. METHODS We used data from a Latin American survey of a total of 400 asthma patients in four Brazilian state capitals, all of whom completed a questionnaire regarding asthma control and treatment. RESULTS In that sample, the prevalenc...

BACKGROUND Although numerous reports have described the clinical features of sarcoidosis in various ethnic and racial groups, many have been limited by small size, homogenous populations, and relatively short follow-up periods. We report the clinical characteristics of a large, race-sex-age diverse cohort of sarcoidosis clinic patients followed in a large university medical center for an extend...

A sensitive protein-binding assay has been used to measure plasma concentrations of total corticosterone during postnatal development in the rat. These concentrations were extremely low on days 6--12, showed a significant rise by day 14, and then continued to rise until peaking on day 24. Plasma titers of corticosteroid-binding globulin rose even more dramatically from day 12 onward. Consequent...