Molecular cloning of the alpha 2A-adrenergic receptor has shown that this receptor is a member of the gene superfamily of guanine nucleotide-binding protein (G protein)-coupled receptors. The alpha 2A-adrenergic receptor expressed in Chinese hamster ovary (CHO) cells attenuates and potentiates forskolin-stimulated cAMP production through independent signaling pathways. To examine the role of th...

introduction: malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. nowadays, molecular targeted therapy has attracted great attention in treatment of glioma. connexin 43 (cx43) and micro ribonucleic acid- 21(mir-21) are among molecules that are involved in glioma development and progression. these molecules showed poten...

Background. In chronic heart failure, the positive inotropic effects of -adrenergic receptor agonists are greatly reduced, in part as a result of two alterations of the cardiac -adrenergic receptors: loss of their function (receptor uncoupling) and reduction of their number (downregulation). In vitro studies have shown that a major mechanism leading to fadrenergic receptor uncoupling involves p...

We describe the cloning and functional expression of a cDNA encoding a novel G protein-coupled receptor, which was isolated from the central nervous system of the pond snail Lymnaea stagnalis. The amino acid sequence predicted by this cDNA shows highest similarity with the sequence of the Locusta tyramine receptor, the Drosophila tyramine/octopamine receptor, and the mammalian alpha-adrenergic ...

Adrenergic beta-receptor sensitivity of six male patients with essential tremor and six age-matched normal controls was assessed by measuring the response in the heart rate and postural tremor to incremental injections of the adrenergic beta-agonist isoprenaline. The relative increase in heart rate and tremor in essential tremor patients did not differ from that in normal controls. It is conclu...

Casey DP, Curry TB, Wilkins BW, Joyner MJ. Nitric oxidemediated vasodilation becomes independent of -adrenergic receptor activation with increased intensity of hypoxic exercise. J Appl Physiol 110: 687– 694, 2011. First published December 30, 2010; doi:10.1152/japplphysiol.00787.2010.—Hypoxic vasodilation in skeletal muscle at rest is known to include -adrenergic receptorstimulated nitric oxide...

An increase in cardiac beta-adrenergic sensitivity or beta-receptor density or both has been described in several animal species after denervating the heart. The transplanted human heart is also denervated and, therefore, may exhibit supersensitivity to beta-adrenergic agonists and an increase in beta-adrenergic receptor density. In 16 patients examined 1-3 months after orthotopic cardiac trans...