179 Many countries run schemes which encourage physicians and other health care professionals to report suspected drug reactions (ADRs). The aims of these spontaneous reporting schemes (SRSs) are to identify previously unsuspected reactions, to elucidate the relevant risk factors, and to evaluate the comparative toxicity of drugs within the same therapeutic class [1,2]. By their nature these sc...

The elderly are at risk for polypharmacy, which is associated with significant consequences such as adverse effects, medication nonadherence, drug-drug and drug-disease interactions, and increased risk of geriatric syndromes. Providers should evaluate all existing medications at each patient visit for appropriateness and weigh the risks and benefits of starting new medications to minimize polyp...

Adverse drug reactions associated with the use of anticancer drugs are a worldwide problem and cannot be ignored. Adverse drug reactions can range from nausea, vomiting or any other mild reaction to severe myelosuppression. The study was planned to observe the suspected adverse drug reactions of cancer chemotherapy in patients aged >18 years having cancer attending Postgraduate Institute of Med...

OBJECTIVE To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age...

http://bmj.com/cgi/content/full/329/7456/44 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/329/7456/44/DC1 "Systems for drug safety research and references" References http://bmj.com/cgi/content/full/329/7456/44#otherarticles 3 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/329/7456/44#...

A CADR is a skin eruption induced by drugs, systemic or topical drugs, used in adequate doses and in the correct indications. CADRs are a frequent problem in Dermatology, but their incidence is not exactly known; 1–5% of inpatients experience such a reaction and it is a frequent cause of consultation in Dermatology [1–5]. Most CADRs are mild, but about 20% can be severe and require hospitalizat...

PURPOSE With the increase in vancomycin use, adverse drug reactions (ADRs) associated with vancomycin have been reported increasingly more often. However, the characteristics of cutaneous ADRs with and without systemic reactions (SRs) have not been described. This study investigated the characteristics of spontaneously reported and assessed ADRs associated with vancomycin by a pharmacovigilance...

BACKGROUND Adverse drug reactions (ADRs) vary from life-threatening anaphylaxis to minor common side-effects. OBJECTIVE To provide an overview on the assessment of ADRs. To discuss the features of what may be described as a 'reaction to a drug' in order to highlight those suggestive of allergy, side-effect or intolerance, and what implications this might have for the future use or avoidance o...

introduction: Cutaneous adverse drug reactions (CADR) from all regions of Oman are monitored by spontaneous adverse reaction reporting and monitoring system. Methods: A total of 100 patients with cutaneous adverse drug reactions were analyzed in a cohort study for 15 months from 1st June 2005 to 31st August 2006. Results: Out of 100, 85 cases were reported in one year time; from 1st of June 200...