The miR-200 family members have been implicated in stress responses and ovarian tumorigenesis. Here, we find that miR-200c/141 transcription is intimately linked to the transcription of the proximal upstream gene PTPN6 (SHP1) in all physiological conditions tested. PTPN6 and miR-200c/141 are transcriptionally co-regulated by two complementary mechanisms. First, a bypass of the regular PTPN6 pol...

Glioblastoma multiforme is one of the most lethal types of brain cancer. With limited success from conventional therapies, the cancer stem cell theory was developed, and investigation into microRNAs (miRs) has facilitated understanding of this theory. The present study demonstrated that miR‑141 is suppressed in sorted cluster of differentiation (CD) 133(+) glioblastoma stem cells (GSCs) compare...

Background: Among all the traffic accidents fractures of skull has significant role because brain humanbeing is in semi-liquid form and more prone to be affected. It co-ordinating controlling whole bodymovements. may cause sudden death or person becomes disabled throughout life.Method: 141 cases different age group head injuries dead bodies broughtfor post-mortem examination, V.SGeneral Hospita...

It is well known that ox-LDL plays key roles in the development of atherosclerosis, partly by inducing vascular smooth muscle cells (VSMCs) proliferation. Recent findings have revealed that microRNAs, a class of small noncoding RNAs, could regulate cell proliferation in many physiological and pathological conditions. However, the role and function of miRNAs on ox-LDL induced VSMC proliferation ...

In ISC 2002, J. Zheng [8] proposed a new public key cryptosystem whose security is based upon the algebraic problem of reducing a high degree matrix to its canonical form by similarity transformations. In this paper, we show that factoring a polynomial over a finite field can be used to break down Zheng’s public key cryptosystem. The complexity of our attack is polynomial time. In other word, t...

Purpose: Transscleral contect-cyclophotocoagulation has been used more end more in the treatment of therapy-refractive glaucomas, in recent years. A less pain sensation, reported by the patients, during b-eatment in comparison with cycle-cryocoagulatio was one important reason for increased usuage. The dose-effect correlation for exposure time, energy used and number of the laser impacts variou...

Evolution of iteroparity is shaped by the trade-off between current and future reproduction. We studied variation in among 205 050 individual Atlantic salmon caught 179 rivers spanning 14° latitude. The proportion repeat spawners (iteroparous individuals) averaged 3.8% ranged from 0% to 26% across rivers. Females were more often than males had lower cost reproduction terms lost body mass spawni...

BACKGROUND Maternal ageing is the only aetiological factor unequivocally linked to aneuploidy. Two mechanisms seem to explain these abnormalities in oocytes: non-disjunction and premature unbalanced separation of sister chromatids (PSSC). Previous studies of unfertilized oocytes argue for a major role of PSSC in the aetiology of aneuploidy for women of advanced age, but in vitro ageing of the o...

Childhood obesity is a global epidemic. Health videogames are an emerging intervention strategy to combat childhood obesity. This systematic review examined published research on the effect of health videogames on childhood obesity. Fourteen articles examining 28 health videogames published between 2005 and 2013 in English were selected from 2433 articles identified through five major search en...