Aging is a multifactorial irreversible process associated with significant decline in muscle mass and neuromuscular functions. One of the most efficient methods to counteract age-related changes in muscle mass and function is physical exercise. An alternative effective intervention to improve muscle structure and performance is electrical stimulation. In the present work we present the positive...

BACKGROUND No study to date has investigated longitudinal trajectories of cardiac autonomic modulation changes with aging; therefore, we lack evidence showing whether these changes occur naturally or are secondary to disease or medication use. This study tested whether heart rate variability (HRV) trajectories from middle to older age are largely normative or caused by pathological changes with...

Introduction: Health care providers play a central role as the main members of the health care service providers team for the elderly and their knowledge and attitudes towards the aging phenomenon can play an important role in the quality of health care services provision for the elderly. Therefore, the present study aims to comparatively investigate knowledge and attitude of health care provid...

For decades, researchers in the biology of aging have focused on defining mechanisms that modulate aging by primarily studying a single metric, sometimes described as the "gold standard" lifespan. Increasingly, geroscience research is turning towards defining functional domains of aging such as the cardiovascular system, skeletal integrity, and metabolic health as being a more direct route to u...

Background Physical and cognitively stimulating recreational activities are lifestyle factors that may modify risk of late-life cognitive decline. We sought to examine the role retrospective ratings mid-life (age 40) physical activity engagement – change in these from age 40 study entry predicting cognition. hypothesized higher self-reported levels at 40, less decline over time, would be associ...

Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest ...

Many studies demonstrate changes in physiology, biochemistry, or behavior with age, but almost no studies demonstrate such changes being predictive of aging. We subsampled from 10 genetically distinct strains of Drosophila melanogaster as they aged, at three time points, measuring change over time of parameters related to water balance (water content, desiccation survival, and K(+), Mg(2+), and...