نتایج جستجو برای: agonists
تعداد نتایج: 40862 فیلتر نتایج به سال:
The development of drugs which stimulate selectively the prejunctional dopamine receptor has become a major challenge in recent years1,2), These autoreceptor agonists decrease synthesis and release of dopamine (OA), Thus, the symptoms of schizophrenia originated from dopamine hyperactivity in the mesolimbic system should be reduced. On the other hand, it has been shown that OA autoreceptor agon...
Zilpaterol hydrochloride is a β-adrenergic agonist, which belongs to a group of compounds known as catecholamines. β-Adrenergic agonists activate β-receptors in muscle and fat causing increased lipolysis, decreased lipogenesis or increased protein accretion (Mersmann, 1998), or both. β-Adrenergic agonists vary greatly in their effect on meat animals. Supplementation of diets with β-agonists can...
prepulse inhibition (ppi), the objective measure of sensorimotor gating disturbance has being widely used in animal models of schizophrenia. dopaminergic direct and indirect agonists impair ppi. however, the profile of dopaminergic receptors involved in ppi impairment by dopamine agonists is not clear. by injecting shrna expressing plasmids against dopamine d2 receptor genes (drd2) in the nucle...
dopamine agonists, particularly nonergot dopamine agonists such as pramipexole, have become the mainstay of therapy for patients with symptoms of restless legs syndrome (rls). this study was designed to evaluate the factors affecting the efficacy of pramipexole in patients with rls. fifty-nine eligible rls patients referred to neurology clinic of rasoul-e-akram hospital (tehran, iran) were recr...
Intralesional therapies offer promise to modulate immune signatures within melanoma and other cancers, either as monotherapy or as a component of combination immune therapy. We have shown that the TLR2/6 agonists (MALP-2 and FSL-1) and IFNg induce human melanoma cells to synergistically produce T-cell attracting chemokine CXCL10. Despite the promise of inducing CXCL10 in the tumor microenvironm...
Various α(2,3) subtype selective partial GABA-A agonists are in development to treat anxiety disorders. These compounds are expected to be anxiolytic with fewer undesirable side effects, compared to nonselective GABA-A agonists like benzodiazepines. Several α(2,3) subtype selective and nonselective GABA-A agonists have been examined in healthy volunteers, using a battery addressing different br...
The orexigenic peptide ghrelin has been shown to have prokinetic activity in the gastrointestinal (GI) system of several species, including humans. In this series of experiments, we have evaluated the prokinetic activity of novel, small-molecule ghrelin receptor (GhrR) agonists after parenteral and peroral dosing in mice and rats. Gastric emptying, small intestinal transport, and fecal output w...
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