BACKGROUND MicroRNA-21 (miR-21) is overexpressed in most inflammatory diseases, but its physiological role in gut inflammation and tissue injury is poorly understood. The goal of this work is to understand the role of miR-21 in colitis and damage progression of intestine in a genetically modified murine model. METHODS Experimental colitis was induced in miR-21 KO and wild-type (WT) mice by 3....

No effective systemic treatment was available for advanced gastrointestinal stromal tumour (GIST) until the introduction of tyrosine kinase inhibitor (TKI) imatinib at beginning millennium, with a median patient survival time just 10 to 20 months.1DeMatteo R.P. Lewis J.J. Leung D. Mudan S.S. Woodruff J.M. Brennan M.F. Two hundred tumors: recurrence patterns and prognostic factors survival.Ann S...

Projection pursuit regression is generalized to multivariate responses. By viewing classification as a special case, this generalization serves to extend classification and discriminant analysis via the projection pursuit approach. Submitted to Journal of the American Statistical Association * Work supported by the Department of Energy under contract DEAC03-76SF00515, by the Office of Naval Res...

3575 Background: The German AIO study KRK-0306 is a randomized phase III trial that investigates the efficacy and safety of cetuximab plus FOLFIRI versus bevacizumab plus FOLFIRI in the first-line treatment of mCRC. Until September 2008, patients (pts) without knowledge of their KRAS mutational status had been enrolled. Here, results of the subgroup of pts with mCRC carrying a mutated KRAS gene...