although most breast cancers are adenocarcinomas of the mammary gland, primary breast sarcomas may also arise from mammary gland mesenchymal tissue. sarcomas represent less than 1% of primary breast neoplasms. these tumors are at high risk of recurrence and are known to have poor prognosis. surgical resection is the primary treatment for these lesions and axillary lymph node dissection is not r...

hamartoma of the breast is a rare benign breast lesion which is unfamiliar to most clinicians, although the mammographic features are usually characteristic. hamartomas are composed of ducts, lobules, fat and fibrous tissue. these benign lesions are likely to be increasingly diagnosed because of routine screening and hence clinical awareness is paramount to prevent these lesions from being over...

A noncontact diffuse correlation spectroscopy (DCS) probe has been developed using two separated optical paths for the source and detector. This unique design avoids the interference between the source and detector and allows large source-detector separations for deep tissue blood flow measurements. The noncontact probe has been calibrated against a contact probe in a tissue-like phantom soluti...

In the present paper, we estimated backscattering factors for the TLD and active personal dosimeters using 662 keV gamma-ray photons on a PMMA surface, which are, for the TLD, 1.12; Dosicard, 1.116; DRD, 0.99; and Saphydose, 1.073, and on a water slab phantom surface; for the TLD, 1.115; Dosicard, 1.112; DRD, 1; and Saphydose, 1.059. The backscattering factor contribution for the Saphydose is n...

BACKGROUND We have developed a new approach to reduce the serum interference for ELISA. The purpose of this study is to investigate if we can use the optimized ELISA (MBB-ELISA) to detect serum soluble HER2/neu (sHER2) in early stage primary breast cancer and monitor its change during treatments. FINDINGS We collected sera preoperatively from 118 primary breast cancer patients. Serum samples ...

HIC-1 is a gene that is hypermethylated in cancer, and commonly downregulated in human breast cancer. However, the precise mechanisms and molecular pathways regulated by HIC-1 remain unclear. We assessed HIC-1 expression on a tissue microarray containing 80 cases of breast cancer. We also analyzed its biological function by restoring HIC-1 expression using 5-aza-2' deoxycytidine (5-CdR) and sma...

BACKGROUND By reducing the specificity associated with loss of information, the influence of attenuation of the breasts is very important in myocardial perfusion studies. However, although several studies have been conducted over the past years, little has been developed to determine accurately the influence of the characteristics of the breasts on the quality of myocardial scintigraphy, avoidi...

The present study aimed to examine the effect of RNA interference targeting cell division cycle‑associated protein 4 (CDCA4) on the proliferation and apoptosis of the MCF‑7/ADR' human breast cancer cell line. CDCA4 has been shown to have a unique role in regulating cell cycle. In the present study, the expression of CDCA4 was suppressed by CDCA4‑specific short hairpin (sh)RNA transfection of th...

Background: Diffusion-weighted imaging (DWI) is one of methods in evaluation of breast lesions. We aimed to investigate the apparent diffusion coefficient (ADC) values in breast tumors and their accuracy in differentiating benign versus malignant lesions. Methods: In this cross-sectional study, 72 patients with 88 breast lesions were investigated by 1.5-T breast MRI from 2015 to 2017 in Athari...

The inferior gluteal artery perforator (IGAP) free flap represents an alternative technique for autogenous breast reconstruction in patients with insufficient abdominal donor tissue. Historically, patients underwent a staged approach for bilateral breast reconstruction with the IGAP because it is technically demanding and can be time consuming. The bilateral simultaneous IGAP can be performed e...