phosphodiesterases  (pde)  hydrolyse intracellular camp  and  cgmp  to  inactive  5’ monophosphates. decreased level of camp is involved in the pathogenesis of asthma. we and others have shown that phosphodiesterases were upregulated in the lung of allergic rats, and bacilli calmette-guérin (bcg) induced the production of camp in vitro. however, it is unclear how bcg’s effect asthma and whether...

Xanthine derivatives may inhibit phosphodiesterases without selective action on their single isoforms. In this study, effects of theophylline and theobromine on cough and airway reactivity were evaluated in awake guinea pigs using double-chamber whole body plethysmograph. Pre-treatment with theophylline and theobromine (10 mg/kg, i.p.) decreased the number of cough efforts evoked by inhalation ...

In this paper, the transmutation of TRUs of the DUPIC (Direct Use of Spent PWR Fuel in CANDU) spent fuel has been studied with the HYPER system, which is an LBE-cooled ADS. The DUPIC concept is a synergistic combination of PWRs and CANDUs, in which PWR spent fuels are directly reutilized in CANDU reactors after a very simple re-fabrication process. In the DUPICHYPER fuel cycle, TRUs are recover...

Increases in asthma worldwide have been associated epidemiologically with expanding urban air pollution. The mechanistic relationship between airway hyper-responsiveness, inflammation, and ambient airborne triggers remains ambiguous. Acrolein, a ubiquitous aldehyde pollutant, is a product of incomplete combustion reactions. Acrolein is abundant in cigarette smoke, effluent from industrial smoke...

Anger has been implicated in the etiology of hypertensive disease. Trait anger has been linked to enhanced cardiovascular responsiveness. However, whether this association reflects differences in context appraisal or a general hyper-reactivity of the cardiovascular system remains unclear. We studied the cardiovascular response to acoustic startle probes in 76 healthy Caucasian males in differen...

In Korea, an accelerator-driven system (ADS) called HYPER (Hybrid Power Extraction Reactor) is being studied for the transmutation of the radioactive wastes. HYPER is a 1 000 MWth leadbismuth eutectic (LBE)-cooled ADS. In this paper, the neutronic design characteristics of HYPER are described and its transmutation performances are assessed for an equilibrium cycle. The core is loaded with a duc...

A(2A) adenosine receptor (A(2A)AR) has potent anti-inflammatory properties, which may be important in the regulation of airway reactivity and inflammation. Inflammatory cells that possess A(2A)AR also produce nitrosative stress, which is associated with pathophysiology of asthma, so we hypothesized that A(2A)AR deficiency may lead to increased airway reactivity and inflammation through nitrosat...