Brinzolamide (BZ) is an intraocular pressure reducing agent with low bioavailability. The purpose of the present study was to overcome this issue by development of BZ containing nanoemulsions (NEs) as an ocular drug delivery system with desirable therapeutic efficacy. Brinzolamide NEs were prepared by the spontaneous emulsification method. Based on initial release studies, twelve formulations w...

Dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. The aim of this study is to develop ocular dorzolamide HCl nanoliposomes (DRZ – nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. Nanoliposomes were prepared using Reverse-phase evaporation vesicle (REV) and thin layer hydration (TLH...

Brinzolamide (BZ) is an intraocular pressure reducing agent with low bioavailability. The purpose of the present study was to overcome this issue by development of BZ containing nanoemulsions (NEs) as an ocular drug delivery system with desirable therapeutic efficacy. Brinzolamide NEs were prepared by the spontaneous emulsification method. Based on initial release studies, twelve formulations w...

pathological changes in pulp and periapical tissues are addressed by endodontic treatment. the material used in this treatment must be biocompatible. the aim of this study is to compare the skin reaction of calcium enriched mixture (cem) and mineral trioxide aggregate (mta) produced in iran on rabbit. sixteen male newzeland albino rabbits weighting 2 kg were used. the animals back hair was shav...

Relaxin, when administered to mice pretreated with estrogen, induces a transformation of the joint cartilage into ligamentous tissue. This transformation , which results in an increased distance between the pubic bones that border the joint, is similar to that occurring during normal pregnancy."'2 The increase in interpubic distance following relaxin treatment has been the chief criterion used ...

Spanish explorers and colonists inadvertently started a massive experiment in evolutionary genetics when they accidentally introduced Avena barbata to California from Spain during the seventeenth and eighteenth centuries. Assays of the Spanish and Californian gene pools of this species for 15 loci show that the present day Spanish gene pool, particularly that of Southwestern Spain, is identical...

Seven strains of Shope fibroma virus were compared for their effect on rabbit cells in vitro. All but one of the naturally occurring strains examined in this study produced a similar response in the infected cultures. This consisted of continued cell multiplication together with changes in cell morphology and growth pattern. In contrast, a recently isolated strain of fibroma virus, the M1 strai...

In Australia, the rabbit haemorrhagic disease virus (RHDV) has been used since 1996 to reduce numbers of introduced European rabbits (Oryctolagus cuniculus) which have a devastating impact on the native Australian environment. RHDV causes regular, short disease outbreaks, but little is known about how the virus persists and survives between epidemics. We examined the initial spread of RHDV to s...

The sink-source conversion in developing leaves of tobacco (Nicotiana tabacum L.) was studied to determine whether import termination is caused by the onset of export or is related to achievement of positive carbon balance. Albino shoots were grown in vitro and grafted to detopped stems of green tobacco plants. Termination of import was studied by providing mature leaves of the stock plant with...