نتایج جستجو برای: alcoholic steatohepatitis
تعداد نتایج: 38571 فیلتر نتایج به سال:
Introduction Chronic liver inflammation leads to liver cirrhosis, which is the 12th leading cause of death in the US (1), accounting for 32,000 deaths in the US and more than 1 million deaths each year worldwide (2). Chronic pathologic processes include viral infection, alcoholic liver disease, nonalcoholic steatohepatitis (NASH), and autoimmune diseases. Depending on the type of underlying liv...
Non-alcoholic steatohepatitis (NASH) is characterized by liver steatosis and inflammation. Currently, the underlying mechanisms leading to hepatic inflammation are not fully understood and consequently, therapeutic options are poor. Non-alcoholic steatohepatitis (NASH) and atherosclerosis share the same etiology whereby macrophages play a key role in disease progression. Macrophage function can...
Nonalcoholic steatohepatitis (NASH) is a condition histologically similar to alcoholic steatohepatitis, yet while the latter has long been recognized as a cause of end-stage liver disease, the former was, until recently, discounted as having a benign course [1–3]. Indeed, it was felt that undisclosed alcohol use must account for those individuals with advanced fibrosis and steatohepatitis [4]. ...
Non-alcoholic fatty liver disease (NAFLD) is a prevalent disease, which features an abnormal accumulation of lipids inside hepatocytes. Steatohepatitis plays a critical role in the process resulting in liver fibrosis and cirrhosis. Curcumin and puerarin are herbal products widely used in Asia, which are believed to have therapeutic benefits for alleviating the symptoms of steatohepatitis. In th...
OBJECTIVE To evaluate the capability of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) to assess steatohepatitis and fibrosis determined by histopathology in type 2 diabetic patients. METHODS Fifty-nine type 2 diabetic patients (49 women, 10 men; mean age, 54 ± 9 years) were submitted to liver biopsy for the evaluation of non-alcoholic fatty liver disease (NAFLD) and und...
Mechanobiology is a rapidly emerging field focused on the biological impact of physical forces at molecular, cellular, and tissue level. Living cells perceive mechanical cues transform them into biochemical signals through mechanotransduction. Mechanotransduction complex process that involves mechanosensors (which are located in plasma membrane or within cell) mechanotransmission to nucleus occ...
Non-alcoholic steatohepatitis (NASH) is becoming a growing public health problem along with the increase of metabolic syndrome worldwide. Extracellular nucleotides are known to serve as danger signal by initiating purinergic signaling in many inflammatory disorders, although role progression NASH remains be clarified. Vesicular nucleotide transporter (VNUT) key molecule responsible for vesicula...
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