PURPOSE We analyzed Asp(835) mutations of FLT3 on paired marrow samples at diagnosis and relapse from 120 adult patients with de novo acute myeloid leukemia (AML) to determine the role of FLT3 Asp(835) mutation in the relapse of AML. EXPERIMENTAL DESIGN Asp(835) mutation was analyzed by DNA PCR amplification of exon 20 of FLT3 gene followed by EcoRV digestion. All of the mutations were confir...

Answer Set Programming (ASP) is a declarative problem solving approach, combining a rich yet simple modeling language with high-performance solving capacities. ASP is particularly suited for modeling problems in the area of Knowledge Representation and Reasoning involving incomplete, inconsistent, and changing information. From a formal perspective, ASP allows for solving all search problems in...

The excitatory amino acid receptors selectively activated by N-methyl-D-aspartate (N-Me-D-Asp) (also known as NMDA) are a major determinant of central nervous system neuronal excitability. We report here that rat brain synaptic plasma membranes contain a distinct population of L-[3H]glutamate binding sites with pharmacological properties indicative of the N-Me-D-Asp receptor. The N-Me-D-Asp sit...

Abstract Answer set programming (ASP) emerged in the late 1990s as a paradigm for knowledge representation and reasoning. The attractiveness of ASP builds on an expressive high-level modeling language along with availability powerful off-the-shelf solving systems. While utility incorporating aggregate expressions has been realized almost simultaneously inception first systems, general semantics...

Literature shows that reinforcement learning (RL) and the well-known optimization algorithms derived from it have been applied to assembly sequence planning (ASP); however, way this is done, as an offline process, ends up generating methods are not exploiting full potential of RL. Today’s lines need be adaptive changes, resilient errors attentive operators’ skills needs. If all these aspects ev...

Long-term outcomes following drug treatment were examined for cocaine-dependent men (N = 453) and women (N = 254) with and without antisocial personality disorder (ASP). In-depth assessments were conducted at treatment intake in 1991-93 and at 1 and 5 years following treatment discharge. Overall, 47.2% of the males and 34.3% of females were diagnosed with ASP using DSM-III-R criteria derived fr...

In recent years answer set programming has been extended to deal with multi-valued predicates. The resulting formalisms allows for the modeling of continuous problems as elegantly as ASP allows for the modeling of discrete problems, by combining the stable model semantics underlying ASP with fuzzy logics. However, contrary to the case of classical ASP where many efficient solvers have been cons...

Treatment of cancer metastasized to bone is still a challenge due to hydrophobicity, instability, and lack of target specificity of anticancer drugs. Poly (ethylene glycol)-poly (ε-caprolactone) polymer (PEG-PCL) is an effective, biodegradable, and biocompatible hydrophobic drug carrier, but lacks bone specificity. Polyaspartic acid with eight peptide sequences, that is, (Asp)8, has a strong af...