OBJECTIVE To present and interpret results of patch testing with the Mayo Clinic standard series over 5 years. DESIGN Retrospective study. A standardized patch testing technique was used. Data were recorded on a standardized computer program from January 1, 2001, to December 31, 2005, and analyzed. SETTING Tertiary referral center. PATIENTS Patients who were referred for patch testing. ...

Both environmental tobacco smoke and indoor allergens can exacerbate already established childhood albeit primarily through quite disparate mechanisms. In infancy and childhood, environmental tobacco smoke (ETS) exposure is associated with measures of decreased flow in the airways, bronchial hyperresponsiveness, and increased respiratory infections, but the relationship between ETS and allergy ...

What we know: Sensitisation to indoor allergens (house-dust mite, cat) is related to the level of exposure to these allergens in early childhood. The prevalence of asthma in childhood is independent of allergen exposure in early life. Asthma occurs in a substantial number of young children in the absence of allergen sensitisation. Asthma and allergic sensitisation have increased in recent decad...

Allergen-specific IgE serology tests became commercially available in the 1980s. Since then these tests have been widely used to diagnose and treat allergic skin diseases. However, the relationship between a positive reaction and disease occurrence has been controversial. The purpose of this study was to evaluate allergens using a serologic allergy test in dogs with atopic dermatitis (AD). Dogs...

investigated by immunoblot with serum from individuals sensitized to anisakis or shrimp. IgE binding patterns in the immunoblots were used for the identification of major Anisakis allergens, which were analysed by mass spectrometry-based proteomics in ESI-Orbitrap, after separation on SDS-gel. Results: Four new allergen candidates were identified. The first identified allergen was enolase, whic...

PURPOSE OF REVIEW In this article we consider the characteristics that are associated with chemical respiratory allergens, and that may be essential for effective sensitization of the respiratory tract. RECENT FINDINGS Chemical respiratory allergens share some characteristics with other chemical allergens, specifically chemical allergens that cause skin sensitization and allergic contact derm...

The prevalence of allergies has vastly increased over recent decades due to air pollution and climate change. The present study aims to identify any seasonal variations in the allergens, to help prevent and treat allergic diseases; and investigate any correlations between the reported allergens and other biotic parameters, namely age and sex. The study included 67 subjects (49 female and 18 mal...

The present study was designed to asses specific IgE towards environment allergens in 42 healthy horses. Determination of this immunoglobulin in serum serve as diagnostic tools in allergic diseases to improve efficacy of the treatment and proper allergen selection to specific immunotherapy. Serum levels of allergen specific IgE were measured with equine monoclonal antibody, using 15 individual ...

Allergenicity of food proteins is a crucial problem associated with the widespread usage of new foods, supplements and herbs, many of them having known or unknown genetically modified origin. Allergenicity is a subtle, non-linearly coded property. Most of the existing methods for allergenicity prediction are based on structural similarity of novel proteins to known allergens. Thus, the identifi...

In Europe and the USA, at least one person in four is exposed every day to inhalant allergens of mammalian origin, a considerable number is regularly exposed for professional reasons and almost everyone is occasionally exposed to inhalant allergens from pets or domestic animals. The production of IgE to these inhalant allergens, often complicated by asthma and rhinitis, defines the atopic statu...