N -nitroso compounds, such as N -nitrosodiethylamine (NDEA), can be formed by the reaction of secundary amines with nitrosating agents, and are suspected to be involved in tumors in humans. NDEA has been considered a weak carcinogen in genotoxic assays probably due to the inefficient nitrosamine activation system that is used and/or to the efficient repair system. In this work, we evaluated the...

PURPOSE The protective effect of Allium vegetables against carcinogenesis has been reported in experimental studies particularly focusing on the gut. Therefore, we conducted a hospital-based matched case-control study to explore the association between dietary Allium consumption and risk of breast cancer among Iranian women in northwest Iran. METHODS A validated, quantitative, food frequency ...

Mineral profile and some selected components of three cultivars of onion (Allium cepa L.) (Dan Zaria, red creole and white creole) bulb were compared with garlic (Allium sativum L.) clove. This was pertinent to establish their potentials in ensuring adequate nutrition and food security. Simultaneous multi-element analysis was done by inductively coupled plasma-optical emission spectroscopy (ICP...

The efficacy of methanolic extracts and powders of 12 spices (Pimpinella anisum, Scorodophleuszenkeii, Xylopiaparviflora, Eugenia caryophyllus, Fagara leprieurii, Fagara macrophylla, Monodora myristica, Olax subscorpioidea, Xylopiaaethiopica, Allium sativum, Zinziber officinale and Cinnamomum zeylanicum) in stabilizing crude soyabean oil during accelerated storage was assessed. The phytochemica...

The objective of the present study was to evaluate the anxiolytic and anticonvulsant activity of the methanolic extract of Allium Cepa Linn (MEAC). After preliminary phytochemical evaluation, acute oral toxicity test, anxiolytic activity of methanolic extract of Allium Cepa bulbs at doses of 200 and 400 mg/kg was assessed using elevated-plus-maze (EPM), open field test (OFT), light & dark trans...

INTRODUCTION Alprazolam is a triazolobenzodiazepine used in panic disorders and other anxiety states. Target organ of Alprazolam is CNS, causing depression of respiration and consciousness. AIM This study aimed to estimate the genotoxic potential of Alprazolam using Allium cepa test. METHODS Allium cepa is one of the most suitable plants for detecting different types of xenobiotics. The tes...

Allium cepa L. is known to possess numerous pharmacological properties. Our aim was to examine the in vitro effects of Allium cepa L. extract (AcE) on Porphyromonas gingivalis LPS and Escherichia coli LPS-stimulated osteoclast precursor cells to determine cell viability to other future cell-based assays. Osteoclast precursor cells (RAW 264.7) were stimulated by Pg LPS (1 μg/mL) and E. coli LPS ...

Leachates from active and closed municipal solid waste landfills can be a major source of contamination to groundwater and surface waters. In the present study the toxic and genotoxic potential of leachate from an old sanitary landfill prior to and following chemical and electrochemical treatments were assessed using Lemna, Allium, and comet tests. Photosynthetic pigments, malondialdehyde (indi...

This study was designed to examine the in vitro antimicrobial and antioxidant activities of the methanol, ethanol, water, n-hexane and dicholoromethane extracts of two Allium species (Allium scabriflorum and Allium tchihatschewii) which are endemic for the flora of Turkey. The antimicrobial efficiency of the plant was evaluated according to disc diffusion and microdilution broth methods. The an...