The presence of a graft-versus-tumor effect has been well established in leukemia but not in multiple myeloma. A 40-year-old patient with myeloma refractory to standard chemotherapy and autologous transplantation received a matched unrelated T-cell-depleted transplant after conditioning with fractionated total-body irradiation, thiotepa, and cyclophosphamide. This procedure resulted in a transi...

In a series of 100 acute myeloid leukemia (AML) patients defined by cytochemistry and immunophenotyping, 20 expressed T-lymphocyte associated antigens on the surface of their blasts. While 15 expressed two or more T-cell antigens, five were found to express only CD7. All patients belonged to the French-American-British type M4, and four were under the age of 40. Despite intensive chemotherapy, ...

Liver transplantation is the only treatment available for acute liver failure. However, mortality rates remain high because of the shortage of donor organs. Indeed up to 20% of patients with acute liver failure may survive without transplantation. In the last two decades, research has focused on the development of alternative or supportive measures to deal with acute liver failure; one of the m...

Abstract IL-10 producing CD4 +type-1 regulatory T cells (Tr1) mediate immune tolerance during chronic infection, autoimmunity, and transplantation. We previously demonstrated that eomesodermin (Eomes) promotes Tr1 cell (Eomes +IL-10 +) development after allogenic bone marrow transplantation (alloBMT). Here we define the differentiation trajectory of functional states therein. Eomes −IL-10 −, −a...

conclusions in iran, hsct has been successfully adapted in routine clinical care. recently, new methods such as double cord blood and haploidentical transplantation have been used to treat many life-threatening diseases. results about 78.2% of the patients (2530 of 3237) remained alive between one to 211 months after stem cell transplantation. nearly, 21.8% (707) of our patients died after stem...

An advance of Hodgkin lymphoma (HL) diagnostic and treatment protocols promoted between fatal high-curative disease. Modern programs can reach many-year survival rate in 8097% even patients with advanced (IIIIV) HL stages unfavorable prognostic factors pre- sence. Nevertheless, relapses refractory (r/r) appears 830% depend on scheme, comorbi- dity. Second-line therapy (ViGePP ICE) is a common p...

background: successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. it has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. transforming growth factor beta (tgf-   β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. recent studies suggest a ...