T lymphocyte progenitors differentiate into two distinct T cell lineages. Although the alpha beta and gamma delta T cell lineages resemble each other phenotypically and functionally, there are some striking differences. Some gamma delta T cells recognize, similarly to alpha beta T cells, peptides presented by major histocompatibility complex (MHC) proteins or MHC-like molecules. However, there ...

We investigated serotonin stimulated palmitoylation of G alpha subunits in rat brain cerebrocortical membranes. Serotonin dose dependently stimulated palmitoylation of membrane G alpha proteins. The highest [H] palmitate incorporation observed was by G alpha-q (7-fold), followed by G alpha-o (5fold), G alpha-i (4-fold) and G alpha-s (3-fold) and these increases in palmitoylation were blocked by...

We have analyzed T-cell receptor delta (TcR-delta) gene rearrangement and transcription in appropriately phenotyped mononuclear cells derived from 12 patients with T-cell acute lymphoblastic leukemia (T-ALL). The T-ALL cells were also analyzed for rearrangement and transcription of the T-cell receptor(TcR)-beta and gamma genes as well as for the presence of TcR-alpha gene transcripts. Four T-AL...

DNA polymerase III holoenzyme has been purified from Escherichia coli HMS-83, using, as an assay, the conversion of coliphage G4 single-stranded DNA to the duplex replicative form. The holoenzyme consists of at least four different subunits: alpha, beta, gamma, and delta of 140,000, 40,000, 52,000, and 32,000 daltons, respectively. The alpha subunit is DNA polymerase III, the dnaE gene product....

Peripheral CD8(+) T cells mainly use CD8alpha/beta, and their development is mainly dependent on the major histocompatibility complex (MHC) class I proteins K(b) and D(b) in H-2(b) mice. In this report, we have shown that the development of CD8alpha/beta TCR-alpha/beta cells in lymphoid organs as well as in intestinal intraepithelial lymphocytes (iIELs) is dependent on the MHC class I K(b) and ...

Based on patterns of employment transitions, we identify three different types workers in the US labor market: α's β's and γ's. Workers type α make up over half all workers, are most likely to remain same job for more than 2 years and, when they become unemployed, typically find a new within 1 quarter. γ comprise less one-fifth have low probability staying face high remaining jobless year. β be...

We have previously characterized a CD3+ T cell receptor (TCR) alpha/beta- human fetal cloned cell line, termed F6C7, which surface-expresses a CD3-associated gamma chain identified by anti-NKFi, an mAb with a restricted clonotypic reactivity. Here, we have produced an additional antibody, anti-Ti-gamma A, which recognizes a public epitope of the gamma molecule defined by anti-NKFi. Ti-gamma A i...