Paraoxonase-1 (PON1) and PON3 (PON3) are anti-atherosclerotic enzymes, synthesized primarily in liver and bound to HDL in circulation. The aim of the present study was to investigate the effects of therapeutic doses of lipoic acid on PON1 and PON3 protein levels, mRNA expression and arylesterase activity in liver. We treated HepG2 cells with 10, 40 and 200 μM lipoic acid for 72 h. Cell viabilit...

OBJECTIVE Assisted reproductive techniques are useful in helping infertile couples achieve successful conception. Initial studies have shown that sperm cryopreservation, one step in assisted reproduction, causes a dramatic reduction in sperm quality. This has been attributed to, among other things, free radical activities. The aim of the present study was to minimize this oxidative attack by ad...

Abbreviations: DGC, dystrophin glycoprotein complex; DAPC, dystrophin associated protein complex; β-DG, Beta-dystroglycan; ALA, Alpha-lipoic acid; L-Car, L-carnitine; CK, creatine kinase; TBARS, thiobarbituric acid reactions; SOD, superoxide dismutase; CAT, catalase; GPx, glutathione peroxidase; MyHC, myosin heavy chain; HO-1, Heme oxygenase-1; NF-κB, nuclear factor-κB; MMP, Matrix Metalloprote...

Potassium permanganate (KMnO4) and oleic acid (OA) were purchased from Alfa Aesar. Glutathione (GSH), 3-(4,5-dimethylthialzol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), alpha lipoic acid (ALA), buthionine sulfoximine (BS) and N-ethylmaleimide (NEM) were purchased from Sigma-Aldrich. Doxorubicin hydrochloride (DOX) was purchased from Dingguo reagent company (Beijing, China). All buffers were p...