Buprenorphine, a mu-opioid partial agonist, has demonstrated efficacy for the treatment of opioid dependence comparable to that of methadone. The clinical utility of buprenorphine would be enhanced if it could be dosed on a less than daily basis. The current study is a parallel-group outpatient clinical trial of daily versus alternate-day dosing with 8 mg sublingual (s.l.) buprenorphine. Partic...

These studies were designed to determine whether the insulin resistance of fasting extends to its antilipolytic effects and whether fasting enhances the lipolytic effects ofadrenergic stimulation independent ofchanges in plasma hormone and substrate concentrations. Palmitate flux was determined isotopically (il-'4Cjpalmitate) before and during epinephrine infusion in normal volunteers after a 1...

OBJECTIVE Verify whether the postoperative fasting period increases the risk for infection and prolonged length of stay. METHODS Prospective cohort study. Elective surgery patients were included. Excluded: those with no conditions for nutritional assessment, admitted in minimal care units, as well as with <72h in-hospital stay. Postoperative fasting was recorded from the days of no nutrition ...

In this paper we discuss the threat of malware targeted at extracting information about the relationships in a real-world social network as well as characteristic information about the individuals in the network, which we dub Stealing Reality. We present Stealing Reality (SR), explain why it differs from traditional types of network attacks, and discuss why its impact is significantly more dang...

background: the pattern of islamic fasting differs from other forms of fasting, therefore its effect on health also differs. this research studies the effect of islamic fasting on gonadotropin hormones around the time of the ovulatory cycle and ovulation. materials and methods: this self-controlled study was performed on 24 adult females. blood sampling was performed during ramadan and two mont...

OBJECTIVE To assess the pharmacokinetics and safety of liquid palivizumab compared with lyophilized palivizumab. METHODS This phase 2, randomized, double-blind crossover study included premature infants aged ≤6 months born ≤35 weeks gestational age. Patients were randomized in a 1:1 ratio to receive a single 15 mg/kg intramuscular dose of liquid (sequence A group) or lyophilized (sequence B g...