نتایج جستجو برای: alveolar macrophages
تعداد نتایج: 117354 فیلتر نتایج به سال:
To evaluate the expression of miR-155 and autophagy in COPD related mechanism. Alveolar macrophages were extracted from patients. dynamic mouse model was established. Mouse alveolar also isolated cultured. Rat macrophage cell line NR8383 introduced. The TLR4 NF-κB cells with CSE treatment evaluated. upregulated bronchoalveolar lavage fluid patients, treated (p < 0.05). Overexpression miR‐155 le...
BACKGROUND & OBJECTIVES Apoptosis is considered as a major defense mechanism of the body. Multiple pathogens induce macrophage apoptosis as a mode of immune evasion. In earlier studies, n-3 polyunsaturated fatty acids (PUFA) have been reported to be protective against neuronal apoptosis and neuronal degeneration, seen after spinal cord injury. In this study, we tried to evaluate the role of n-3...
Acute exposure to particulate matter (PM) air pollution causes thrombotic cardiovascular events, leading to increased mortality rates; however, the link between PM and cardiovascular dysfunction is not completely understood. We have previously shown that the release of IL-6 from alveolar macrophages is required for a prothrombotic state and acceleration of thrombosis following exposure to PM. H...
DAP12 is an adapter protein that associates with several receptors in macrophages. Little is known about the biological role of DAP12 in alveolar macrophages. In genome-wide profiling, we previously found that two DAP12-associated receptors, myeloid DAP12-associated lectin-1 and triggering receptor expressed on myeloid cells 2 (TREM2), were highly induced in alveolar macrophages from habitual s...
A case of high altitude pulmonary oedema (HAPE) in a climber who made a rapid ascent on Mt McKinley (Denali), Alaska is described. The bronchoalveolar lavage (BAL) fluid contained increased numbers of red blood cells and an abundance of haemosiderin laden macrophages consistent with alveolar haemorrhage. The timing of this finding indicates that alveolar haemorrhage began early during the ascen...
man tissues and blood cells. In particular, @32adrenergic receptor effects on lymphocytes and gran ulocytes have been probed extensively.' Recently, Liggett2 identified and characterized @32-adrenergic receptors in human alveolar macrophages responding to specific stimulation with an increase of intracellular cyclic adenosine monophosphate (cAMP). This increase in cAMP has striking inhibitory e...
There is growing evidence that amorphous silica nanoparticles cause toxic effects on lung cells in vivo as well as in vitro and induce inflammatory processes. The phagocytosis of silica by alveolar macrophages potentiates these effects. To understand the underlying molecular mechanisms of silica toxicity, we applied a co-culture system including the immortal alveolar epithelial mouse cell line ...
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