Primary biliary cirrhosis is predominantly seen in middle-aged women. Typical symptoms are fatigue, pruritus, and abdominal pain. Jaundice develops in the endstage disease. At presentation, about 40% of the patients are asymptomatic, but 30% to 50% already have hepatomegaly, and 15% present with splenomegaly. Even patients with fully developed liver cirrhosis may be free of symptoms. Abnormal p...

BACKGROUND Human epithelial cell adhesion molecule (EpCAM) is overexpressed in many cancers. Anti-EpCAM antibodies have shown promise in preclinical studies, but showed no tumor regression in a recent phase II clinical trial. Therefore, we generated a novel anti-EpCAM antibody-drug conjugate and assessed whether it showed enhanced antitumor effects. METHODS Chemical cross-linking was conducte...

The in vitro activity of carumonam (Ro 17-2301; AMA-1080) was tested against 355 single-patient isolates, by and large enteropathogenic or nonfermentative rods. The new monobactam was inhibitory and bactericidal against the majority of diarrhea-causing members of the family Enterobacteriaceae at concentrations of less than and equal to 8 micrograms/ml. Although known to be active against Pseudo...

Mutations in the Caenorhabditis elegans RNA polymerase II AMA-1/RPB-1 subunit that cause α-amanitin resistance and/or developmental defects were isolated previously. We identified 12 of these mutations and mapped them onto the Saccharomyces cerevisiae RPB1 structure to provide insight into AMA-1 regions that are essential for development in a multicellular organism.

Antimitochondrial antibodies (AMA) were detected in the sera of 11 of 36 patients with a clinical diagnosis of polymyalgia rheumatica (PMR) in whom comprehensive autoantibody screening had been performed. AMA did not correlate with biochemical changes of hepatic dysfunction, which are common in PMR, nor with parameters of musculoskeletal inflammation. Possible explanations are discussed.

FirstRand decided on the AMA not only because of the capital savings that could be obtained, but also to achieve world-class, sophisticated risk management using state-of-theart technology and techniques. The use of an AMA requires the implementation of various risk management processes, subprojects and measurement components that support good, accurate risk measurement, management and reporting.

The Ama have existed for more than 2000 years in Japan and Korea. They have been diving for seaweed and molluscs. Their traditional way of fishing, with goggles or a mask, but without a wetsuit, is still practised as a result of laws against overfishing. We investigated cardiovascular diving responses, expressed as heart rate (HR) reduction, peripheral vasoconstriction indicated by skin blood f...

This was a historic summer in Chicago for emergency medicine. On July 18, 2015, John W. Becher, DO, became the 119th president of the American Osteopathic Association (AOA), while a month earlier, on June 9, 2015, Steven J. Stack, MD, became the 170th president of the American Medical Association (AMA). This is the first time that emergency physicians have led the two largest professional physi...

BACKGROUND Improvement in swimming performance involves the dynamic alignment of the body in liquid, technical skill, anthropometric characteristics of athletes, and the ability to develop propulsive force. The aim of this study was to assess the relationships between the propulsive force during swimming and arm muscle area (AMA) and propose an equation to estimate the propulsive force in young...