Amination of phenylene moieties in crystal-like mesoporous silica hybridized with phenylene is successfully achieved with close to 28% conversion of phenylene by a two-step chemical transformation process while preserving both the ordered mesostructure and crystal-like molecular scale periodicity of the parent material.

This work reports the isolation and spectroscopic characterization of pentavalent metal–imido species that are reactive towards N-group transfer reactions including alkene aziridination C–H amination.

The reductive amination/cyclization of biomass-based keto acids and amines to lactams under mild condition with ammonia borane (NH3–BH3) as the hydrogen donor in absence additives is reporte...

The application of silica-supported TEMPO as a recyclable catalyst in the Anelli oxidation of alcohols is reported. The catalyst is easily obtained in a one-step reductive amination procedure starting from a commercially available aminopropyl-functionalized silica. Details of the synthesis of the supported catalyst and its analysis by MAS NMR are presented. Various alcohol oxidations according ...

Stannylated allylic carbonates are suitable substrates for Pd-catalyzed allylic aminations. In DMF and with [allylPdCl](2) as catalyst the stannylated allyl amines formed can be directly coupled with electrophiles according to the Stille protocol, giving rise to highly functionalized building blocks in excellent yields.

D-Glutamate inhibited hyphal extension, the degree of inhibition depending on the identity of the glutamate dehydrogenase (GDH) enzyme present in the mycelium. Mycelia were most sensitive to inhibition on media which promoted formation of the NAD-linked GDH. The activity of this enzyme was inhibited by D-glutamate in experiments with cell-free extracts, the inhibitions being noncompetitive or m...

Valine dehydrogenase was purified to homogeneity from the crude extracts of Streptomyces aureofaciens. The molecular weight of the native enzyme was 116,000 by equilibrium ultracentrifugation and 118,000 by size exclusion high-performance liquid chromatography. The enzyme was composed of four subunits with molecular weights of 29,000. The isoelectric point was 5.1. The enzyme required NAD+ as a...

The large scale industrial manufacture of the nasal decongestant pseudoephedrine is typically carried out by the reductive amination of l-phenylacetylcarbinol (l-PAC), which in turn is produced via the biotransformation of benzaldehyde using yeast. In recent years there has been increasing legislative control of the supply of pseudoephedrine due to it being diverted for the clandestine producti...

Abstract Amination and amidation of aryl compounds using a transition-metal-catalyzed cross-coupling reaction typically involves prefunctionalization or preoxidation of either partner. In recent years, a new class of transition-metal-catalyzed cross-dehydrogenative coupling reaction has been developed for the direct formation of aryl C–N bonds. This short review highlights the substantial progr...

Cationic rhodium(I) complexes containing the flexible hemilabile phosphine ligand (3-ethoxypropyl)diphenylphosphine efficiently catalyzed the anti-Markovnikov oxidative amination of styrene in tetrahydrofurane at 80 degrees C to produce (E)-1-styrylpiperidine with turnover frequencies up to 75 h(-1) with excellent enamine selectivity (96%).