Preclinical studies and clinical trials carried out within the past few years have provided a premise that gamma-aminobutyric acid (GABA) transmission and GABA(B) receptors play a modulatory role in the mechanism of action of different drugs of abuse. The present review summarizes the contribution of GABA(B) receptors to the rewarding, locomotor and discriminative stimulus properties of drugs o...

In addition to its role in the adult mammalian nervous system as an inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) is involved in the proliferation, differentiation, and migration of several kinds of cells including cancer cells. GABA is synthesized predominantly from glutamate by glutamate decarboxylase and exerts its effects via ionotropic GABA(A) receptors and/or metabotropic GA...

Objective: Clinical and laboratory studies have demonstrated that prelimbic (PrL) serotonin-4 (5-HT4) receptors may the key role in regulating anxiety. However, pathophysiology of anxiety Parkinson’s disease (PD) remains obscure. In this research, effects PrL 5-HT4 on anti-anxiety behaviors hemiparkinsonian rats were investigated. Methods: PD model used as research subjects, starting with behav...

Abstract This study aimed to screen the lactic acid bacteria (LAB) strain that has high potential in gamma-aminobutyric (GABA) production and antibacterial properties, which could be applied Vietnamese fermented meat ( Nem chua ) fermentation. These bacterial strains were isolated from commercial products stored laboratory. GABA synthesized 18 of LAB MRS media adding 3% MSG was qualitative quan...

The γ-aminobutyric acid (GABA) content and distribution of mung bean (MB), heat relative humidity treated MB (HRH-MB) under different cooking storage conditions were investigated. quality characteristics noodles prepared by HRH-MB evaluated. Results showed that black varieties presented a higher average GABA HRH treatment than green varieties. Soaking significantly increased the (P < 0.05), but...

Most high γ-aminobutyric acid (GABA) producers are Lactobacillus brevis of plant origin, which may be not able to ferment milk well due to its poor proteolytic nature as evidenced by the absence of genes encoding extracellular proteinases in its genome. In the present study, two glutamic acid decarboxylase (GAD) genes, gadA and gadB, were found in high GABA-producing L. brevis NPS-QW-145. Co-cu...

Gamma Aminobutyric Acid (GABA), also known as 4-aminobutyric acid, of which the molecular formula is C4H9NO2, with a relative molecular weight of 103.2. It widely exists in the cells of microorganism, animals and plants, as a kind of neuro-inhibitory transmitter in mammals, a variety of physiological and metabolic activities are involved. It is greatly demanded by the market for the special phy...

?-Aminobutyric acid (GABA) and glucagon-like peptide-1 receptor agonist (GLP-1RA) improve rodent ?-cell survival function. In human ?-cells, GABA exerts stimulatory effects on proliferation anti-apoptotic effects, whereas GLP-1RA drugs have only limited proliferation. We previously demonstrated that sitagliptin (Sita), a dipeptidyl peptidase-4 inhibitor which increases endogenous GLP-1 levels, ...

γ-Aminobutyric acid (GABA) can accumulate in apple fruit response to stress, but little is known about the responses of GABA treatments. The hypothesis that would inhibit physiological disorder development ‘Honeycrisp’ apples has been tested a three-year study. In 2015, trees were sprayed with 40 mM 2 and 4 weeks before harvest, harvested stored at 0.5 °C, chilling injury-inducing temperature, ...

Streptococcus thermophilus strain B59671 is a Gram-positive lactic acid bacterium that naturally produces a broad-spectrum bacteriocin, thermophilin 110, and is capable of producing gamma-aminobutyric acid (GABA). The complete genome sequence for this strain contains 1,821,173 nucleotides, 1,936 predicted genes, and an average G+C content of 39.1%.