The impact of bacterial adherence on antibiotic activity was analyzed with two isogenic strains of Staphylococcus epidermidis that differ in the features of their in vitro biofilm formation. The eradication of bacteria adhering to glass beads by amikacin, levofloxacin, rifampin, or teicoplanin was studied in an animal model and in a pharmacokinetically matched in vitro model. The features of S....

We present spectroscopic, photometric and astrometric observations of four bright L dwarfs identified in the course of the 2MASS near-infrared survey. Our spectroscopic data extend to wavelengths shortward of 5000Å in the L0 dwarf 2MASSJ0746+2000 and the L4 dwarf 2MASSJ0036+1840, allowing the identification of absorption bands due to MgH and CaOH. The atomic resonance lines Ca I 4227Å and Na I ...

This paper proposed an efficient reduction method of voltage drop (IR) at the core of high density IC’s chips. The presented method is based on branching out several layer of metals from the I/O bond-pads of power supply and feed them to the core of the chip through a data and other non power supply pads. Hence, the up most two layers of metals (M6, M7) for seven layers of metals technology are...

Myelodysplastic syndrome (MDS) is characterized by clonal hematopoiesis and impaired differentiation, may develop to acute myeloid leukemia (AML). We explored the mechanism of histone methyltransferase EZH2/EHMT2 during transformation MDS into AML. Expression in patients NHD13 mice was detected. EZH2 EHMT2 were silenced or overexpressed SKM-1 cells. The cell proliferation cycle evaluated. Level...

OBJECTIVE: To determine the frequency of proptosis and associations with demographic, clinical hematological characteristics acute myeloid leukemia (AML) in children. METHODS: This descriptive study was conducted at Combined Military Hospital, Rawalpindi, Pakistan from January 2018 to July 2020. Patients AML between 1-12 years age who presented without orbital granulocytic sarcomas (OGS), selec...

Abstract This translational study aimed at gaining insight into the effects of lenalidomide in acute myeloid leukemia (AML). Forty-one AML patients aged 66 or older Swiss cohort HOVON-103 AML/SAKK30/10 were included. After randomization, they received standard induction chemotherapy with without lenalidomide. Bone marrow biopsies diagnosis and before 2nd cycle obtained to assess therapeutic imp...

the hematological malignancies associated with nephrotic syndrome are mainly hodgkin’s and non-hodgkin’s lymphomas and chronic lymphocytic leukemia. acute myelogenous leukemia (aml) has rarely been described in associated with nephritic syndrome. we report a rare case of acute myelogenous leukemia who presented with nephrotic syndrome. a previously healthy 62-year-old man was admitted in nephro...

BACKGROUND AML with myelodysplasia related changes (AML MRC) is known to show a poor prognosis compared with de novo AML, but controversies exist about the prognostic impact of multilineage dysplasia (MLD) among MRC. We investigated the prognostic impact of MLD in AML MRC. METHODS A total of 357 patients newly diagnosed as AML at Asan Medical Center from January 2001 to December 2005 were ana...

Each poly(A) containing cytoplasmic AD-2 MRNA contains at its 5' terminus the general structure m7 GpppN1 pN2p or m7 GpppN1mpN2mpNp as well as an average of 4 m6A and 0.5-1 m5C residues per molecule. Almost all of the N1m residues are adenine derivatives including Am, m6Am and probably m26,6Am. The N2m is mostly Cm but small amounts of the other three methylated bases are also present. All the...