To investigate the Epidermal Growth Factor Receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) in Yunnan province in southwestern China, we detected EGFR mutation by Amplification Refractory Mutation System (ARMS) polymerase chain reaction (PCR) using DNA samples from 447 pathologically confirmed NSCLC specimens (175 tissue, 256 plasma and 16 cytologic samples). The relationsh...

background: bladder cancer (bc) is the most common genitourinary cancer in iranians with an unclear etiopathogenesis. long stress induced non-coding transcript 5 is a member of the 12-member family of long non-coding rnas, which is abundantly expressed in higher proliferative cells, as well as the cell vulnerable to cellular stress in response to chemical carcinogens. as variations in long non-...

background: single-nucleotide polymorphism (snp) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (ptpn22) has been shown to be a risk factor for different autoimmune diseases. this study explored the association of 1858 c/t snp with rheumatoid arthritis (ra) and celiac disease (cd) in a region covering south-west of iran. methods: totally, 52 patients with cd, 120 patien...

conclusions the results revealed a significant relationship between the gg genotype of ctla-4 and the increased risk of tb. results data analysis indicated that the frequencies of aa, ag and gg genotypes were 42%, 38%, and 20% in patients with tb and 43%, 47%, 1% in the control subjects, respectively. the gg genotype of ctla-4 (+49a/g) showed a significantly increased risk of disease (or = 20.4...

background interleukine-12 (il-12) induced interferon-γ (ifn- γ) production and development of t cells into th1 cells, which has a critical role in immunity to intracellular pathogens. objectives the current study aimed to evaluate the possible association between il12a rs568408, il12b rs3212227 as well as il-12 receptor (il-12r) rs383483 polymorphisms and pulmonary tuberculosis (ptb). methods ...

background: human leukocyte antigen-e (hla-e)is a non-classical major histocompatibility complex (mhc) class i antigens which expressed on extra villous cytotrophoblast, which interacts with nkg2a, is an inhibitory receptor on natural killer (nk) cells and leading to down regulation of immune response in the maternal-fetal interface and provides maternal immune tolerance of the fetus. objective...