This paper reviews the mechanisms of anaphylactic shock in terms of the immunoglobulin and non-immunoglobulin triggering events, and the cellular events based on the rise in intracellular cyclic AMP and calcium that release preformed granule-associated mediators and the rapidly formed, newly synthesized mediators predominantly based on arachidonic acid metabolism. These primary mediators recrui...

The alpha-gal allergy is an emerging IgE-mediated reaction against the galactose-alpha-1,3-galactose carbohydrate found in mammalian meats. Patients with this condition will develop anaphylactic symptoms 3-6 h after the ingestion of mammalian meat food products such as beef, pork or lamb. The prevalence of this allergy is drastically increasing and severe reactions including anaphylactic shock ...

Sir, Adverse reactions from sunscreen ingredients have been increasingly reported, including allergic and irritant contact dermatitis, phototoxic and photoallergic reactions, contact urticaria and even severe anaphylactic reactions (1). UV filters, the active sunscreen components, are more frequently being added to cosmetic products such as lipsticks and moisturizing creams. Moreover, the varie...

in medicine, patent blue violet (pbv) is utilized for staining lymphatic vessels in sentinel lymph node (sln) surgery. moreover, pbv (also called e131 ) is used as food additive. we report on a 51-year-old non-atopic female with early breast cancer, who was scheduled for sln excision and experienced an intra-operative anaphylactic reaction. in diagnostics the skin prick test (spt) was positive ...

The pathogenesis of anaphylactic shock is not completely understood. Mast cell degranulation products may stimulate endothelial cells, leading to activation of fibrinolytic and coagulation systems. We investigated the activation of these systems in insect-sting anaphylaxis. Fifty-five patients with a previous insect-sting anaphylactic reaction and 8 volunteers were challenged with an in-hospita...

1. Typical lethal anaphylactic shock has been produced in guinea pigs by means of the specific carbohydrate derived from a human strain of tubercle bacillus. The phenomenon has been observed in animals both actively and passively sensitized. 2. Typical contractions have been evoked in the isolated uterus of guinea pigs upon the addition of the specific carbohydrate to the bath. 3. True anaphyla...

BACKGROUND Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injection of thymoglobulin are rare. CASE PRESENTATION We report a case of serious anaphylactic reaction occurring after a first intraoperative injection of thymoglobulin during renal...

Methods We present the case of a 31 y.o. woman with repeated anaphylactic reactions most of them upon eating at oriental restaurants. A vast allergic study was carried out in another center ruling out allergy/intolerance to several food additives and foods. The key fact for the diagnosis was an anaphylactic reaction upon eating home-made humus made of chickpea, olive oil and sesame oil. We perf...

3. Blazowski L. Anaphylactic shock because of sublingual immunotherapy overdose during third year of maintenance dose. Allergy. 2008;63:374. 4. de Groot H, Bijl A. Anaphylactic reaction after the first dose of sublingual immuno-therapy with grass pollen tablet. Allergy. 2009;64:963--4. 5. Dunsky EH, Goldstein MF, Dvorin DJ, Belecanech GA. Anaphylaxis to sublingual immunotherapy. Allergy. 2006;6...

A case of anaphylaxis occurring during a general anesthesia is presented. The reaction was severe with bronchospasm and hypotension (grade 2 in the severity of per-operative anaphylactic shock). The responsibility of hydroxyzine, administered for premedication was suspected by intradermal testing with the molecule, which was twice positive at a 10(-2) dilution of the commercial solution. The sa...