Abstract Rhabdomyosarcoma is the most common sarcoma of childhood, and this tumor third neoplasm after neuroblastoma nephroblastoma. Rhabdomyosarcomas may originate in any anatomical site, occurring predominantly head neck regions, orbits, skull base, nasal cavity, nasopharynx, where there little or no musculoskeletal tissue. The involvement ear mastoid bone rhabdomyosarcoma uncommon. embryonal...

background & objectives: anaplastic lymphoma kinase (alk) is a receptor tyrosine kinase involved in the genesis of several human cancers. alk was initially identified because of its involvement in anaplastic large cell lymphoma (alcl). alk is believed to foster tumorigenesis following activation by autocrine and/or paracrine growth loops. studies reveal that the presence of anti-alk antibod...