Histone deacetylase inhibitors (HDACI) are promising antitumor agents. Although transcriptional deregulation is thought to be the main mechanism underlying their therapeutic effects, the exact mechanism and targets by which HDACIs achieve their antitumor effects remain poorly understood. It is not known whether any of the HDAC members support robust tumor growth. In this report, we show that HD...

The syntrophins and alpha-dystrobrevin form a subcomplex with dystrophin at the skeletal muscle membrane, and are also highly concentrated at the neuromuscular synapse. Here we demonstrate that the different syntrophins and alpha-dystrobrevin isoforms have distinct expression patterns during human skeletal muscle development, and are differentially affected by loss of dystrophin anchorage and d...

A serum-free assay has been established for studying the role of polypeptide growth factors in inducing loss of density-dependent inhibition of growth of normal rat kidney (NRK) cells. The process has been characterized by measuring the time course of [3H]thymidine incorporation into confluent, quiescent NRK cultures stimulated by defined polypeptide growth factors, in combination with cell cou...

Joan Eamer, Environment Canada, Whitehorse, Yukon, Canada; Etok Edwardsen, Fairbanks, Alaska; Carl Jack, Rural Alaska Community Action Program (RurAl CAP), Anchorage, Alaska; Suzanne Marcy, U.S. Environmental Protection Agency, Anchorage, Alaska; Angie Olrun, Aleutian/Pribilof Islands Association, Anchorage, Alaska; Michael Patkotak, Barrow, Alaska; Delbert Rexford, Barrow, Alaska; Alex Whiting...

The idea of absolute anchorage has always been an elusive goal for clinicians. Orthodontic mini-implants or temporary anchorage devices allow tooth movements previously thought to be impossible or difficult. Although extensive literature exists on use of temporary anchorage devices, their failures have been hardly focused upon, especially implant fracture. The following case report describes su...

This study investigates the dynamic characteristics of a smart PZT interface mounted on prestressed anchorage to verify numerical feasibility admittance-based anchor force monitoring technique. Firstly, technique through single-mount is outlined. The admittance response interface-anchorage system theoretically derived show proof-of-concept for monitoring. Secondly, finite element model correspo...