Traumatic brain injury (TBI) is one of the main causes of mortality and morbidity worldwide. Despite extensive investigations over the past few decades, no effective therapies exist to improve the brain function in patients with TBI. Neural tissue engineering is an attractive therapeutic approach to restore the brain structure and function of damaged tissue. Bioactive motif of Stromal cell-deri...

While migration is a basic element of population dynamics in most societies, in Iran, rural-urban migration is a particular concern of both social scientists and policy makers. Rural-urban migration accounts for over half of the growth of most Iranian cities. On the other hand, this movement is often cited as having negative effects on rural area, including a shortage of supply of agricultural ...

mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. peroxisome proliferator-activated receptor gamma (pparγ) is a member of the large nuclear hormone  receptor  transcription  factor  superfamily, and  has  been  recently implicated in the anti-inflammatory response. to investigate a possible role for pparγ in human mast cells, we studied the ...

Migration of an agent involves various security problems especially in heterogeneous environment. Most of the reviewed studies for securing the mobile agent depended on one security technique. The proposed model integrates well known security techniques in four security levels: securing Mobile Agent Using Agent Factory & Blueprint, securing Mobile Agent Blueprint, securing Mobile Agent Migratio...

Myocyte enhancer factor 2B (MEF2B) is a transcription factor with mutation hotspots at K4, Y69 and D83 in diffuse large B-cell lymphoma (DLBCL). To provide insight into the regulatory network of MEF2B, in this study, we analyse global gene expression and DNA-binding patterns. We find that candidate MEF2B direct target genes include RHOB, RHOD, CDH13, ITGA5 and CAV1, and that indirect target gen...

The WAVE family of proteins has long been implicated in the stimulus-dependent generation of lamellipodia at the leading edge of migrating cells, with WAVE2 in particular implicated in the formation of peripheral ruffles and chemotactic migration. However, the lack of direct visualisation of cell migration in WAVE2 mutants or knockdowns has made defining the mechanisms of WAVE2 regulation durin...

During brain development, proper neuronal migration and morphogenesis is critical for the establishment of functional neural circuits. Here we report that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains in vivo and in vitro. P...

In this paper, we consider the extent to which the aggregate happiness of a country affects the flow of people across its borders. We merge data from the World Values Survey, which produces happiness indices for 84 countries between 1981 and 2004, with three different migration datasets. We find that happiness has a U-shaped relationship with emigration rates: emigration rates fall in happiness...