Proteins are involved in various equilibria that play a major role in their activity or regulation. The design of molecules that shift such equilibria is of great therapeutic potential. This fact was demonstrated in the cases of allosteric inhibitors, which shift the equilibrium between active and inactive (R and T) states, and chemical chaperones, which shift folding equilibrium of proteins. H...

We propose a method to define constraint weight parameters of the Hopfield network in order to establish the solutions of the optimization problem as stable equilibrium points in the state space. Application of the methodology is demonstrated on a well known benchmark problem, the Traveling Salesman Problem. Simulation results indicate that the proposed bounds on the constraint weight parameter...

Crystal structures of acetylcholinesterase complexed with ligands are compared with side-chain conformations accessed by native acetylcholinesterase in molecular dynamics (MD) simulations. Several crystallographic conformations of a key residue in a specific binding site are accessed in a simulation of native acetylcholinesterase, although not seen in rotomer plots. Conformational changes upon ...

So far, most equilibrium concepts in game theory require that the rewards and actions of the other agents are known and/or observed by all agents. However, in real life problems, agents are generally faced with situations where they only have partial or no knowledge about their environment and the other agents evolving in it. In this context, all an agent can do is reasoning about its own payof...

in this paper, two sets of sufficient conditions are obtained to ensure the existence and stability of a unique equilibrium point of unforced first-order fuzzy relational dynamical systems by using two different approaches which are both based on the fuzzy relational matrix of the model.in the first approach, the equilibrium point of the system is one of the centers of the related membership fu...

The problem ofgeneralized equilibrium problem is very general in the different subjects .Optimization problems, variational inequalities, Nash equilibrium problem and minimax problems are as special cases of generalized equilibrium problem. The purpose of this paper is to investigate the problem of approximating a common element of the set of generalized equilibrium problem, variational inequal...

Evolution and the maintenance of polymorphism under the multilocus Levene model with soft selection are studied. The number of loci and alleles, the number of demes, the linkage map, and the degree of dominance are arbitrary, but epistasis is absent or weak. We prove that, without epistasis and under mild, generic conditions, every trajectory converges to a stationary point in linkage equilibri...

The objective of this paper is to control the phase shifting by applying a bias DC voltage and changing the mechanical characteristics in electrostatically-actuated micro-beams. This problem can be more useful in the design of micro-phase shifters, which has not generally been investigated their mechanical behavior. By presenting a mathematical modeling, Galerkin-based step by step linearizatio...