Among the 170 million HCV-infected subjects worldwide (around 34 million) HCV-G4 accounts for approximately 20% of those infected. This population accounts for most new infections, with limited access to therapy. While in the US HCV-G4 is responsible for 1–2% of HCV infection, in the Middle East and Sub-Saharan African regions it is the main cause of HCV infection, with Southern Europe also det...

M a i n r e s u l t s Plasma exchange: At 4 weeks, more patients who received plasma exchange than supportive care improved by ≥ 1 disability grade (Table). Mean improvement in disability grade was greater in the plasma exchange group than in the supportive care group (4 RCTs, n = 585) (weighted mean difference [WMD] −0.89, 95% CI −1.14 to −0.63). The number of patients still on a ventilator 4 ...