Androgen deprivation therapy (ADT) is a mainstay of prostate cancer treatment, given the dependence cells on androgen and receptor (AR). However, tumors become ADT-resistant, there need to understand mechanism. One possible mechanism upregulation AR co-regulators, although only handful have been definitively linked disease. We previously identified Mediator subunit MED19 as an co-regulator, rep...

This study tested the hypothesis that testis/reproductive tract abnormalities induced in the rat by neonatal treatment with diethylstilbestrol (DES) result from disturbance of the androgen-estrogen balance. Male rats were treated neonatally with a dose of DES (0.1 micro g) that induced either no or small effects on its own or with a dose (10 micro g) that induced major reproductive tract abnorm...

introduction: complete androgen insensitivity syndrome (previously called testicular feminization) is specified by a 46 xy karyotype and negative sex chromatin, bilateral undescended testes, female genitalia appearance, and lack of mullerian derivatives. discussion: our medline search revealed that this is the first reported case of bilateral sertoli–leydig cell tumor (slct) in androgen insensi...

The illicit use of anabolic androgenic steroids (AAS) among adolescents and young adults is a major concern due to the unknown unpredictable impact AAS on developing brain consequences this mental health, cognitive function behaviour. present study aimed investigate effects supra-physiological doses four structurally different (testosterone, nandrolone, stanozolol trenbolone) neurite developmen...

The objective of the review is to explain pathogenesis, causes and various treatment involved in hirsutism. This article discusses disease’s diagnosis. looks at main significant type hairs clinical studies on role several lifestyle therapies hirsutism development. examines numerous methods that order discover new medicaments. In addition, it covers therapy. Hirsutism, reported have strongest im...