An epidemiological and genetical study of osteogenesis imperfecta (OI) in Victoria, Australia confirmed that there are at least four distinct syndromes at present called OI. The largest group of patients showed autosomal dominant inheritance of osteoporosis leading to fractures and distinctly blue sclerae. A large proportion of adults had presenile deafness or a family history of presenile cond...

THE GROUP of diseases characterized by McKusick as generalized "heritable disorders of connective tissue" includes the Marfan syndrome, the Ehlers-Danlos syndrome, osteogenesis imperfecta, the Hurler syndrome, and pseudoxanthoma elasticum. With the exception of osteogenesis imperfecta, all of these have been known to involve significant cardiovascular abnormalities.' The Marfan syndrome is freq...

It has been noted in the literature that Osteogenesis Imperfecta is frequently mistaken for non-accidental injury. This article serves to illustrate the difficulty in differentiating between the two conditions and that they can occur concomitantly in one patient.

mon condition. It is a familial disease characterised by multiple fractures and bending of bones, often associated with blue sclera and otosclerosis. A family in which three out of four issues were affected with this malady, was investigated in September 1952 in the Orthopaedic Department of the Medical College Hospitals, Calcutta. Although isolated cases have been encountered in this departmen...

Hyperplastic callus in osteogenesis imperfecta is rare. The present case is added to the few previously recorded (Brailsford 1943, Baker 1946, Fairbank and Baker 1948) because it illustrates radiographically the development of the condition. An additional point of interest is the occurrence of a fracture of another bone during treatment, without the formation of hyperplastic callus. The patient...