Recent determinations of the E2/M1 ratio are reviewed. Many aspects of these studies have been questioned. Here we focus on the selection of a database, methods used in the extraction of this ratio, and interpretation(s) of the results. I. THE DATA: OLD VS NEW Soon after the Baryons ’92 conference, the VPI group wrote a short note [1] claiming a value of −1.5± 0.5% for the E2/M1 ratio a value i...

S100C is a member of the S100 family of EF-hand-type Ca(2+)-binding proteins which are thought to bind to and thereby regulate the activity of cellular target proteins in a Ca(2+)-dependent manner. An intracellular ligand for S100C is the Ca2+/phospholipid-binding protein annexin I and we show here that complex-formation is mediated through unique domains within S100C and annexin I. Using a pro...

A member of the annexin XIII sub-family, annexin XIIIb, has been implicated in the apical exocytosis of epithelial kidney cells. Annexins are phospholipid-binding proteins that have been suggested to be involved in membrane trafficking events although their actual physiological function remains open. Unlike the other annexins, annexin XIIIs are myristoylated. Here, we show by immunoelectron mic...

Cytokinesis requires the formation of an actomyosin contractile ring between the two sets of sister chromatids. Annexin A2 is a calcium- and phospholipid-binding protein implicated in cortical actin remodeling. We report that annexin A2 accumulates at the equatorial cortex at the onset of cytokinesis and depletion of annexin A2 results in cytokinetic failure, due to a defective cleavage furrow ...

We discuss the choice of gauge field basis in multiple–U(1) gauge theories. We find that there is a preferred basis, specified by the charge orthogonality condition, in which the U(1) gauge fields do not mix under one–loop renormalization group running. VPI–IPPAP–99–02 hep–ph/9903362 March 1999 ∗electronic address: [email protected] †electronic address: [email protected]

We have reported that heat shock protein 27 (HSP27) and annexin II are involved in the protection of human cells against UVC-induced cell death. In this study we tried to confirm the combined roles of HSP27 and annexin II in cell death after UVC irradiation. In RSa cells with sensitivity to UVC, expression of annexin II decreased after UVC irradiation, but not in AP(r)-1 cells with increased re...

El virus de la parainfluenza bovina tipo 3 (VPI-3) es considerado como uno los patógenos más importantes asociados con las enfermedades respiratorias bovinas. Está calificado parte del complejo respiratorio bovino, porque una enfermedad multifactorial asociada a manifestación diferentes agentes etiológicos que causan neumonía o infección vías superiores, en todas edades ganado. ampliamente dist...

Annexins constitute a family of calcium and membrane binding proteins. As annexin A1 and A2 have previously been linked to various membrane trafficking events, we initiated this study to investigate the role of these annexins in the uptake and intracellular transport of the bacterial Shiga toxin (Stx) and the plant toxin ricin. Once endocytosed, both toxins are retrogradely transported from end...