Today, drug resistance is one of the major problems in fight against cancer. Therefore, combination of therapeutic strategies was raised to effectively improve disease prognosis. In this regard, silver nanoparticles (AgNPs) are considered significant due to their anticancer properties. This study aimed to return sensitivity to cisplatin to A2780 cisplatin-resistance cell lines in the presence o...

introduction: apoptosis is a major consequence of ionizing radiation in proliferative tissues and quantification of the apoptotic cells could be helpful for noninvasive assessment and estimation of the radiation absorbed dose. annexin v conjugated with super paramagnetic iron oxide nanoparticles (anx-spio) is a biological probe for detection of apoptotic cells using magnetic resonance imaging. ...

purpose: to design and manufacture iodine 125 radioactive plaques which can be used in patients with ocular melanoma, and to evaluate the efficacy of plaques in an animal model. methods: this prospective basic study was performed in collaboration with farabi hospital and tehran atomic energy agency. the iodide 125 plaques were designed and manufactured based on the collaborative ocular melanoma...

Background & aimsAlthough bortezomib as one of the first line medicines that has greatly improved overall survival patients with multiple myeloma (MM), undesired drug resistance is frequently observed. Docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) have been shown to be able enhance efficacy chemotherapeutic drugs in many cancer types. The aim present study was further evaluate anticance...

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the ability to selectively trigger cancer cell apoptosis and can be used as a target for tumor therapy. However, gastric cells are usually insensitive TRAIL so reducing this drug resistance may improve treatment of cancer. In study, we Cell Counting Kit-8 (CCK-8) 5-ethynyl-2′-deoxyuridine (EdU) experiments determine effects 5-f...

Hepatocellular carcinoma or hepatoma is a primary malignant neoplasm that responsible for 75–90% of all liver cancer in humans. Nanotechnology introduced the dual drug nanodelivery method as one initiatives nanomedicine therapy. Graphene oxide (GO) loaded with protocatechuic acid (PCA) and chlorogenic (CA) have shown some anticancer activities both passive active targeting. The physicochemical ...

Osteoarthritis (OA) is a chronic joint disease with high prevalence. However, effective treatment options for OA are still lacking. It was previously reported that LINC00473 upregulated in patients and might be associated the progression of OA; however, role remains to investigated. CHON-001 human chondrocyte cells stimulated 10 ng/mL interleukin (IL)-1β were utilized mimic vitro. Protein expre...

calcium-binding proteins play essential roles in the cell. one important class of calcium-binding proteins is the annexin family. this is a family of 13 proteins, which binds to phospholipids in a calcium-dependent manner. osteosarcoma cell line (mg-63) is a transformed cell that has many characteristics of the differentiated cell, such as a considerable serum dependency in its growth rate. usi...

reduction of methoxyketon 1 by nabh4 gives methoxyketol 2. allthough acetate and tosylate of this alchohol were not seprated, benzoate ester was isolated. reduction of ketol 2 by lialh4 gives alchohol 4. ketol 9 does not react with methyl magnesium iodide, but methoxyketon 1 react with both methyl magnesium iodide and phenyl magnesium iodide gives corresponding hydrocarbons. keton 13 with pheny...